摘要
为探索米非司酮作为紧急避孕的合适剂量，本研究对避孕失败或未避孕同房７２ ｈ 内要求紧急避孕的６６０例妇女，随机单次服米非司酮１０ ｍ ｇ 或２５ ｍ ｇ。结果：１０ ｍ ｇ 组３２１例中妊娠３例，２５ ｍ ｇ 组３３９例中妊娠４例，均明显低于预期妊娠数，组间差异不明显。避孕有效率分别为８８．２４％ 和８３．４３％ ，副反应轻微。两组分别有１４．１５％ 和２１．１９％ 的服药者周期延长３天以上，组间差异显著（Ｐ＜ ０．０５）。本研究提示１０ ｍ ｇ 和２５ ｍ ｇ 两种剂量的米非司酮皆为合适的紧急避孕剂量。对月经的影响而言１０ ｍ ｇ 组优于２５ ｍ ｇ 组。
To explore the suitable dose of mifepristone as an emergency postcoital contraception,from November 1997 to August 1998,660 health women with unprotected intercourse or contraceptive failure were recruited.They all attended the clinic within 72 h after intercourse and were randomly doubleblind allocated into two groups and were given mifepristone at a single dose of 10 mg in group Ⅰ (n=321),25 mg in group Ⅱ (n=339).The pregnancy rate was calculated by Dixon's method.There were 3 and 4 pregnancies in group Ⅰ and Ⅱ respectively.The contraceptive effective rate were 88.24% and 83.43% respectively.There was no statistically significant difference between the two groups.The side effects of mifepristone were slight and tolerable to by all subjects.There were 14.15% and 21.19% users had delayed menses over three days respectively.This result shows that these two lowdose mifepristone could be used as an effective emergency postcoital contraception,but the influence on the following mense seems to be decreased in the 10 mg dose group,compared with the 25 mg dose group.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1999年第6期352-356,共5页
Reproduction and Contraception
关键词
米非司酮
紧急避孕
月经周期
Mifepristone, Emergency contraception, Menstrual cycle
