摘要
134例要求终止妊娠的妇女（停经≤49天）随机分成两组,分别1次口服米非司酮200mg,25mg,2次/日,连服5次,然后均于第3天上午口服米索前列醇600μg。完全流产率为94.8%,不全流产率为4.5%,1例继续妊娠（0.7%）,两组间均无明显差异。对象自诉的不适症状程度轻微,无需特殊处理。结果提示与米非司酮配伍终止早孕时,适合口服的PGE<sub>1</sub>类似物米索前列醇可取代非口服的PG类似物（如磺前列酮、ONO802和PG05）。
This paper reported that 134 women asking for termination of early pregnancy divided into two groups in random, were orally administered with mifepristone (RU486) either 200mg in single dose (group 1) or 25mg b. i. d for five doses (group I). followed by one oral dose (600μg) of misoprostol. The results showed that in total the rate of complete abortion was 94. 8%,that of incomplete abortion 4. 5% and in one case (0. 7%) live pregnancy was continuing. There was no significant difference between two groups. Complaints reported by the subjects were rather mild. The results indicated that the orally active PGE_1 analogue misoprostol would be an alternative to injectable and vaginal PG preparations such is sulprostone, gemeprost (ONO802) and PG05 (dl-15-methyl PGF_2 mthyl ester).
出处
《中国计划生育学杂志》
1992年第2期19-23,63,共6页
Chinese Journal of Family Planning
关键词
米索前列醇
米非司酮
人工流产
misoprostol mifepristone(RU486) induced abortion
