摘要
探讨ＨＩＶ携带者或ＡＩＤＳ病人（简称ＨＩＶ／ＡＩＤＳ）与肝炎病毒感染者的ＣＤ４＋、ＣＤ８＋淋巴细胞变化，并进行比较。方法：用免疫磁珠法（ＤＹＮＡｂｅａｄｓ）检测ＣＤ４＋、ＣＤ８＋淋巴细胞数，用双侧ｔ检验进行统计学处理。结果：全部ＨＩＶ／ＡＩＤＳ的ＣＤ４＋Ｔ淋巴细胞降低，且幅度大，８３．４％低于５００细胞／ｕｌ。在病毒性肝炎中降低的百分比和幅度均明显低于前者，只有２８．８％低于５５细胞／ｕｌ，且２４．２％大于８００细胞／ｕｌ。与同一水平ＣＤ４＋细胞相对应的ＨＩＶ／ＡＩＤＳＣＤ８＋Ｔ淋巴细胞水平显著高于病毒性肝炎，ＣＤ８＋细胞水平随ＣＤ４＋Ｔ细胞增加而升高。ＣＤ４＋细胞平均水平较高的ＨＩＶ感染者自觉症状与ＣＤ４＋Ｔ细胞数之间无直接相关关系，说明只用ＣＤ４＋Ｔ细胞数来估计病人机体状态或只根据病人症状估计机体免疫状态是不太准确的。结论：ＨＩＶ／ＡＩＤＳ与病毒性肝炎存在不同程度的ＣＤ４＋、ＣＤ８＋Ｔ淋巴细胞异常；ＣＤ４＋Ｔ细胞是ＨＩＶ／ＡＩＤＳ的重要指标，但不是绝对指标；ＣＤ８＋Ｔ细胞与病人病情的变化及预后之间可能存在着很重要的关系，需进一步研究。
Objective: To study and discuss the change of CD4+ .CD8+ T lymphocyte in HIV/AIDS and viral hepatitis patients. Methods:DYNA beads method was performed to count the CD4+, CDS+ T lymphocyte. Statistical analysis was done using bio-t test. Results: CD4+Tlymphocyte counts in all of the HIV/AIDS Patients were much lower than healthy peoplee,83 .4% of them were lower than 500 cell/ul. CD4+ Tlymphocyte counts decreased in hepatitis too, but only 28. 8% were lower than 500 cell/ul,24. 2% were higher than 800 cell/ul. CD8+ T lymphocyte counts were much higher in HIV/AIDS Patients than in hepatitis patients with same CD4+ T lymphocyte level. There was not direct correlation between sympton and CD4+ T lymphocyte level in HIV infected person, so can neither estimate the condition of patients only use CD4+T lymphocyte counts nor estimate the immune status Only with the patients condition. Conclusion: Both HIV/AIDS and viral hepatitis have abnormal CD4+, CD8+ T lymphocyte counts at different level. CD4+ T lymphocyte counts is an important parameter in HIV/AIDS, but it is not anabsolute Parameter. There Aught be a very vaportant relationship exist between CD8+ T lymphocyte level and the clinical course of patients.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第12期561-563,共3页
Chinese Journal of Immunology
