摘要
目的：从分泌抗狂犬病毒糖蛋白单克隆抗体（ＩｇＭ）杂交瘤细胞中提取核糖核酸，研究其抗狂犬病毒的作用。方法：腹腔注射该种核糖核酸４ｗ后用狂犬病毒ＣＶＳ株进行颅腔攻击。结果：该核糖核酸能明显延长动物的生存时间。结论：该核糖核酸对狂犬病毒且有一定的抵抗作用。
Objective: TO Study the possibility of RNA extracted from hybridoma cell as RNA and the relation between this RNA and tranditional RNA. Methods: Extracting RNA from the hybridoma cell which secrets monoclonal antibody(IgM)against the G-Protein of Tabies virusand injecting these RNA into cranial cavity in four weeks.Results: The RNA eextracted from hybridoma cell could delay the dying of force Obviously. Conclusion: The RNA extracted from hybridoma cell had the same function as the traditional immune RNA,wihch could Provided a newnethod to study the mechanism of immune RNA.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第12期542-544,共3页
Chinese Journal of Immunology
关键词
免疫核糖核酸
杂交瘤
单克隆抗体
狂犬病毒
Immune RNA (iRNA)
Hybridoma cell
Monoclonal antibody
Rabies virus
