摘要
目的:研究小叶杜鹃总黄酮-聚乙烯吡咯烷酮(PVP)固体分散体的最佳制备工艺。方法:选用L9(34)正交表设计试验,以固体分散体中总黄酮2 h累积溶出率作为评价指标,采用减压干燥法制备小叶杜鹃总黄酮-PVP固体分散体。结果:小叶杜鹃总黄酮固体分散体的最佳制备工艺为加6倍量载体,6倍量乙醇溶解,减压干燥2 h,干燥温度60℃。结论:小叶杜鹃总黄酮-PVP固体分散体对小叶杜鹃总黄酮有很好的增溶效果。
Objective：To optimize preparation process for total flavonoids from Rhododendron Capitatum Maxim-PVP solid dispersions.Method：To establish experiment by orthogonal design test.Decompress dryness was used to prepare the solid dispersions,using dissolution in vitro to determine optimum technologic parameters.Result： Optimum process was established as following：6 times carriers,6 times alcohol as solvent,2 h as drying time,dryng temperature was 60 ℃.Conclusion：Total flavonoids of Rhododendron Capitatum Maxim solid dispersion prepared with PVP could increase dissolution of total flavonoids obviously.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第23期18-20,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
四川省教育厅青年基金项目(09205036)
西华大学重点科研基金项目(Z0820504)
四川省重点学科资助
关键词
小叶杜鹃
总黄酮
固体分散体
正交试验
减压干燥法
体外溶出度
Rhododendron Capitatum Maxim
total flavonoids
solid dispersion
orthogonal design
decompress dryness
dissolution in vitro
