摘要
背景:已有将多孔钛植入小型骨缺损的报道。目的:验证多孔钛修复兔桡骨节段性骨缺损的疗效。方法:成年健康新西兰大白兔21只,建立双侧桡骨10mm缺损模型,骨缺损处分别植入多孔钛和多孔羟基磷灰石材料。结果:材料植入后第4,8,16周取材观察:①4周时多孔钛组和多孔羟基磷灰石组在材料与宿主骨交界处均有少量骨痂形成,第8和16周时孔隙被新生骨组织填充,与自体骨吻合好。②第8,16周时多孔钛组新骨细胞长入量和骨重建效果几乎接近多孔羟基磷灰石组。两组骨面积在新生骨质长入量上差异无显著性意义(P>0.05)。③第8,16周时多孔钛组的最大承载负荷值明显优于多孔羟基磷灰石组。表明多孔钛支架材料可以促进新骨的形成并有利于节段骨缺损的修复。
BACKGROUND： Usage of porous titanium in the repair of bone defects in animal models has been reported. OBJECTIVE： To investigate the therapeutic effects of porous titanium on the recovery of rabbit radial bone defects. METHODS： A total of healthy 21 New Zealand rabbits were artificially made to be bone defect models by resecting the 1 cm substantial ossea with periosteum of both radii. The left anterior limbs were implanted porous titanium, while the right anterior limbs were implanted porous hydroxyapatite （HA）. RESULTS： ①The gross observation and X-ray results demonstrated that there was a little callus filled in the juncture of materials and autogenous bone both in the left and right anterior limbs 4 weeks after the operation. At 8 and 16 weeks, the materials in the both sides were filled by newly formed bone, and the anastomosis status was good. ②The histology examination showed that mass newly formed bone grew into most pores of both specimens. Along with prolongation of times after operation, the ingrowths of bone cells and effect of bone remodeling in the affected side were nearly as same as the control side at 8 and 16 weeks. The results of histomorphometrical analysis showed that a statistically significant difference was not obtained for % bone area （bone area/gross implant） between the both groups （P 0.05）. ③However, the results of maximum failure load in the affected side were better than those of the control side at 8 and 16 weeks. Osteogenesis can be promoted by porous titanium, which is an appropriate tool to induce the healing of segmental bone defects.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第42期7805-7808,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家重点基础研究发展计划(973)资助项目(G2005cb623901)
国家重点科技攻关支撑计划资助项目(2006BAI16B01)~~
