摘要
背景:异种松质骨具有天然多孔结构,有利于新骨长入,经处理可完全消除抗原性,不引起免疫排斥反应,具有良好的骨传导性能。目的:评价异种骨修复兔桡骨节段性骨缺损的效果。方法:将36只新西兰白兔随机均分3组,制作单侧15mm桡骨节段性骨缺损模型,实验组植入生物型异种骨,对照组植入深冻兔异体骨,空白组未植骨。术后4,8,12周进行一般情况、大体解剖、X射线及组织学观察。结果与结论:术后4,8,12周实验组与对照组骨缺损逐步修复,空白组骨缺损未修复,实验组与对照组影像学和组织学评分均高于空白组(P<0.05),实验组与对照组影像学和组织学评分差异无显著性意义。表明生物型异种骨可较好修复骨缺损,修复效果与异体骨相当。
BACKGROUND： Xenogeneic cancellous bone has a natural porous structure that facilitates the ingrowth of new bone. Besides, its antigenicity can be eliminated completely after treatment and cannot induce immune rejection. Moreover, it has good bone conduction. OBJECTIVE： To evaluate the effect of xenogeneic bone on the repair of segmental bone defects in rabbit radius METHODS： Totally 36 rabbits （4 6 months old, 2.5 3.5 kg, no gender limitations） were randomly divided into three groups： experimental group, control group and blank group. A rabbit model of 15 mm-long segmental bone defects in the radius was established. Rabbits in the experimental group were implanted with biological xenogeneic bone, and those in the control group were implanted with deep frozen allogenic bone, while the blank group had no treatment. At weeks 4, 8 and 12 after operation, rabbits in the three groups were observed by general observation, anatomy observation, X-ray examination and histological examination. RESULTS AND CONCLUSION： At weeks 4, 8 and 12 after operation, bone defects in the experimental and control groups were repaired gradually, but no repair was found in the blank group. The radiographic and histological scores were both higher in the experimental and control groups than the blank group （P 〈 0.05）. The radiographic and histological scores between the experimental and control groups had no significant difference. These results suggest that biological xenogeneic bone is good to repair bone defects; in addition, the repair effect of biological xenogeneic bone is the same as that of xenogeneic bone.
出处
《中国组织工程研究》
CAS
CSCD
2012年第29期5379-5383,共5页
Chinese Journal of Tissue Engineering Research
基金
广东冠昊生物科技股份有限公司及其动物中心对本实验提供资金和技术支持
课题名称:骨诱导型可降解吸收生物活性骨修复材料产业化
项目类型:2008年度广州市生物产业重大专项项目(2008A1-E4051)~~
