摘要
骨组织平衡由行使骨形成和骨吸收的成骨细胞(osteoblast,OB)和破骨细胞(osteoclast,OC)共同维持。在骨重建中两种细胞之间相互调节,一方面,OB、前体细胞、基质细胞调节OC的数量和活性;另一方面,OC反过来也可以调节OB的功能,从而形成一个反馈通路。OB和OC之间的相互调节有助于骨重建过程中骨吸收和骨形成的偶联。近年来,OB对OC骨吸收的调节已有较多研究,尤其是,OPG/RANKL/RANK信号系统的发现对于理解OB对OC骨吸收的调节是一个巨大的飞跃。但OC对OB的调节研究相对较少。本综述讨论了OB和OC之间的相互调节作用,综述了RANKL/RANK/OPG系统在骨形成和骨重建中的作用。
Objective Skeletal homeostasis is maintained by bone forming cell osteoblasts （OB） and bone resorbing cell osteoelasts （ OC）. They modulate each other in the remodeling of the bone. On one hand, OBs, precursor cells,and stroma ceils regulate the number and activity of OC. On the other hand, OCs can also reversely regulate OB function to form a feedback pathway. The interaction between osteoclasts and osteoblasts can help to connect bone resorption and formation in the remodeling process. Recently,there have been some researches on the OB regulation to OC bone resorption, especially the discovery of RANKL/ RANK/OPG system is a huge progress. However,researches on OC regulation to OB are relatively rare. This paper reviews the inter-modulation between osteoblasts and osteoelasts,and mainly focuses on the function of RANKL/RANK/OPG system in bone formation and remodeling.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第11期1010-1013,共4页
Chinese Journal of Osteoporosis
基金
国家自然科学基金资助项目(30970867)
