摘要
目的:观察老年性骨质疏松症患者骨代谢生化指标的特征,探讨其在诊断骨质疏松中的作用。方法:随机选取以L2的骨密度确诊的老年性骨质疏松症患者50例,检测C7、左股骨颈的骨密度,外周血清白细胞介素-6(IL-6)、骨钙素、碱性磷酸酶(ALP)、一氧化氮(NO)含量;空腹尿羟脯氨酸、尿肌酐含量的检测,并与对照组比较。结果:老年性骨质疏松症患者C7和左股骨颈的骨密度降低;骨代谢指标外周血清IL-6、骨钙素、ALP和NO含量均升高以及空腹尿羟脯氨酸/肌酐比值也升高,与对照组比较差异有显著性意义(P<0.05)。结论:老年性骨质疏松症患者C7、左股骨颈的骨密度,外周血清IL-6、骨钙素、ALP、NO含量和空腹尿羟脯氨酸/肌酐比值有一定程度的改变。
AIM:To observe the characteristics of biochemical indexes of bone metabolism in patients with senile osteoporosis,and to explore its application in the diagnosis and treatment of osteoporosis. METHODS:Fifty patients with senile osteoporosis, who were diagnosed by the L2 bone mineral density(BMD),were selected randomly, and their BMD of L2,C7 and left neck of femur,peripheral blood levels of interleukin 6(IL 6),osteocalcin(OC),alkaline phosphatase(ALP),nitric oxide(NO);fasting urinary hydroxyproline(Hyp) and creatinine(Cr) were determined,and then the results were compared with those in the control group. RESULTS:BMD of C7 and left neck of femur in the senile osteoporosis group was decreased; Serum levels of IL 6,OC,ALP,NO and fasting urinary Hyp/Cr were significantly increased,which were significantly different from those in the control group(P< 0.05). CONCLUSION:BMD of C7 and left neck of femur,peripheral blood levels of IL 6,OC,ALP,NO,and fasting urinary Hyp/Cr are changed to some degree in patients with senile osteoporosis.
出处
《中国临床康复》
CSCD
2004年第18期3596-3597,共2页
Chinese Journal of Clinical Rehabilitation
