摘要
目的:通过研究白细胞介素-1α(IL-1α)在中耳胆脂瘤和肉芽组织中的表达情况,探讨其在中耳炎发病机制中的作用。方法:通过免疫组化二步法观察IL-1α在47例中耳炎患者中耳胆脂瘤、肉芽组织和正常外耳道皮肤中的表达,并采用计算机图像分析系统对其表达进行分析。结果:IL-1α在胆脂瘤中的表达灰度值与其骨质破坏能力呈负相关(r=-0.890,P<0.01),在肉芽组织中的表达灰度值与其骨质破坏能力亦呈负相关(r=-0.844,P<0.01)。结论:IL-1α在胆脂瘤和肉芽组织形成过程中发挥着重要的作用,且与胆脂瘤和肉芽组织引起的骨质破坏能力相关。
Objective： To study the expression of（IL-1α） in human middle ear cholesteatoma and granulation tissue and discuss their roles in the pathogenesis of otitis media.Methods： The expression of IL-1α in cholesteatoma,granulation tissue and skin of external auditory canal were observed by immunohistochemistry method in 47 cases of patients with chronic otitis media,and the results were analyzed by the computer image analysis system.Results： The grey value of IL-1α were negatively related with the cholesteatoma′s bone resorption（r=-0.890,P0.01）,or in the granulation tissue（r=-0.844,P0.01）.Conclusion： IL-1α plays an important role in the formation of cholesteatoma and granulation tissue,which also is related with the bone resorption.
出处
《中国医药导报》
CAS
2011年第33期29-30,33,共3页
China Medical Herald
关键词
中耳炎
胆脂瘤
肉芽组织
白细胞介素-1Α
Otitis media
Cholesteatoma
Granulation tissue
Interleukin-1-alpha
