摘要
目的:观察分析支气管动脉灌注化疗联合静脉化疗治疗老年中晚期肺癌的疗效。方法:老年中晚期非小细胞肺癌患者45例,均经病理诊断明确,并行支气管动脉灌注化疗及全身静脉化疗2个疗程以上,每次治疗期间均观察患者支气管动脉血管情况,应用酶联免疫吸附试验(ELISA)测定患者血清血管内皮生长因子(VEGF)的浓度并对患者进行疗效及耐受性的评价。结果:45例老年中晚期肺癌中19例治疗有效(CR+PR),占42.2%,其中血供丰富型28例,治疗有效率为46.4%,乏血供型17例,治疗有效率为35.29%。血供丰富型肺癌行支气管动脉灌注化疗联合静脉化疗有效率较乏血供型肺癌明显提高。治疗有效患者血清VEGF浓度[(69.08±51.29)ng/L]显著低于治疗前浓度[(108.10±68.88)ng/L],差异有统计学意义(t=3.32,P=0.003 8),肿瘤进展的患者血清CEGF浓度[(83.86±49.26)ng/L]与治疗前浓度[(86.49±62.28)ng/L]相仿,差异无统计学意义(t=0.27,P=0.791 3)。结论:支气管动脉灌注化疗联合静脉化疗治疗老年中晚期肺癌是一种有效的治疗方法,观察支气管动脉血供情况及VEGF的变化有利于评价老年性肺癌患者的预后。
Objective： To observe the clinical effects of bronchial arterial infusion chemotherapy combined with intravenous chemotherapy in the treatment of elderly patients with medium and advanced lung cancer. Methods： The concentrations of serum vascular endothelial growth factor （VEGF） were determined by using the enzyme-linked immunosorbent assay （ELISA） , and the blood supply of lung bronchial artery was observed during each treatment period to evaluate the efficacy and tolerability of the 45 elderly patients with medium and advanced non-small cell lung cancer, who were diagnosed by pathology, and were conducted with bronchial artery infusion chemotherapy and systemic intravenous chemotherapy for more than 2 courses. Results： Among the 45 elderly patients with medium and advanced lung cancer, 19 cases received effective treatment （CR±PR）, accounting for 42.2%. Among the 45 elderly patients, 28 cases were the sufficient blood supply type, with the effective treatment rate of 46.4%, while 17 cases were the insufficient blood supply type, with the effective treatment rate of 35.29%. The effective rate of bronchial arterial infusion chemotherapy combined with intravenous chemotherapy significantly increased in the sufficient blood supply type compared to the insufficient blood supply type. The serum VWGF concentrations [（69.08±51.29） ng/L] of patients after receiving effectiye treatment were significantly lower than those before treatment [（108.10±68.88） ng/L], with statistically significant difference （t=3.32, P=0.003 8）. The serum VEGF concentrations of patients [（83.86±49.26） ng/L] in tumor progression and those before treatment [（86.49±62.28） ng/L] were similar, with no statistically significant difference （t=0.27, P=0.791 3）. Conclusion： Bronchial arterial infusion chemotherapy combine with intravenous chemotherapy is an effective method in the treatment of elderly patients with medium and advanced lung cancer. Observation of bronchial artery blood supply and VEGF changes are beneficial to evaluating the prognosis of elderly patients with lung cancer.
出处
《中国医药导报》
CAS
2011年第31期69-71,共3页
China Medical Herald
关键词
老年
支气管动脉灌注化疗
静脉化疗
非小细胞肺癌
血管内皮生长因子
Elderly
Bronchial arterial infusion chemotherapy
Intravenous chemotherapy
Non-small cell lung cancer
Vascular endothelial growth factor
