摘要
目的评价联合介入化疗对接受中医治疗的晚期老年肺癌患者免疫功能的影响,旨在探索一种针对此类患者在疗效、不良反应及治疗费用均可接受的综合治疗模式。方法将60例老年肺癌患者分为纯中医组、联合介入组各30例,分别采用单一中医治疗、中医治疗联合介入化疗进行治疗2个疗程(6～8周),并应用流式细胞仪检测血清中T细胞亚群CD3、CD4、CD8、CD4/CD8、NK细胞以及CD4+CD25+Treg细胞水平。结果两组血清T细胞亚群水平及CD4+CD25+Treg细胞水平在治疗前无显著差异(P>0.05),治疗2个疗程(8周)后,两组血清T细胞亚群水平仍无显著差异(P>0.05);但联合介入组CD4+CD25+Treg细胞水平下降较纯中医组明显,差异有统计学意义(P<0.05),同时近期疗效评价显示联合介入组有效率为40%,临床总获益率为73.3%;均优于纯中医组有效率20%,临床总获益率63.3%。结论对于接受中医治疗为主的晚期老年肺癌患者联合介入化疗并不会导致其免疫功能受损,同时显示有较好的近期疗效,并可能通过有效降低其抑制性T细胞水平而提高疗效,提示中医联合介入化疗作为晚期老年肺癌患者一种新的综合治疗模式值得进一步研究。
Objective To investigate the influence of interventional chemotherapy combined with traditional Chinese medicine on the immune function in elderly patients with advanced lung cancer and to establish a comprehensive therapeutic pattern which is effective and economical with lower side-effects.Methods A total of 60 aged patients with lung cancer were randomly and equally divided into two groups with 30 patients in each group.Patients in group A were purely treated with traditional Chinese medicine and patients in group B were treated with a combination of interventional chemotherapy and traditional Chinese medicine.And two therapeutic courses （6-8 weeks） were conducted in both groups.The serum T-lymphocyte subsets levels of CD3,CD4,CD8,CD4 /CD8,NK cells and CD4＋CD25＋Treg cell levels were estimated with flow cytometry.The results were statistically analyzed.Results No significant difference in serum levels of T cell subsets and CD4＋CD25＋Treg cell levels existed between the two groups,both before and after the treatment （P 0.05）.However,after the treatment the CD4＋CD25＋Treg cell level in group B was significantly lower than that in group A （P 0.05）.The short-term effective rate and the total clinical benefit rate in group B were 40% and 73.3% respectively,which were much better than those in group A （20% and 63.3% respectively）.Conclusion Interventional chemotherapy combined with traditional Chinese medicine will not damage the immune function of elderly patients with advanced lung cancer,on the contrary,the combination therapy,through effectively reducing the suppressor T cell level,shows excellent short-term effect.It indicates that interventional chemotherapy combined with Chinese medicine is an effective comprehensive therapeutic mode for elderly patients with advanced lung cancer.
出处
《介入放射学杂志》
CSCD
北大核心
2010年第6期489-492,共4页
Journal of Interventional Radiology
基金
上海中医药大学附属岳阳中西医结合医院院级课题基金资助
关键词
老年肺癌
介入化疗
免疫功能
中医治疗
lung cancer
aged patient
interventional chemotherapy
immune function
traditional Chinese medicine
