期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

阿托伐他汀对急性脑梗死患者血清抵抗素水平的影响 被引量：6

暂未订购
导出
摘要 目的探讨阿托伐他汀对急性脑梗死患者血清抵抗素水平的影响。方法选取急性动脉粥样硬化性血栓性脑梗死(ACI)患者74例,随机分为对照组及试验组,每组37例。2组均给予常规治疗,试验组在常规治疗基础上给予阿托伐他汀20 mg,1次/晚,口服,对照组给予辛伐他汀20 mg,1次/晚,口服,共3周,测定ACI患者治疗前后的血清抵抗素、血糖、血脂等指标。结果 2组患者血清抵抗素、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(HDL-C)均降低,且试验组明显低于对照组,差异有统计学意义(P<0.01)。结论他汀类药物可降低血清抵抗素水平,改善血管内皮功能,预防动脉粥样硬化形成,从而防止动脉粥样硬化性血栓性脑梗死形成。
作者 王琪 吴一峰 王书秀 安晓蕾 郭秀华 侯文华 高娟梅 郭建昌
机构地区 河北省邯郸市人民医院 河北省邯郸市第一医院 河北省武安市人民医院
出处 《河北医药》 CAS 2011年第22期3415-3416,共2页 Hebei Medical Journal
关键词 阿托伐他汀 抵抗素 脑梗死
分类号 R743.33 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

  • 1Hotamisligil GS. The role of TNF alpha and TNF receptors in obesity and insulin resistance. Intern Meal, 1999,245:621.
  • 2刘玉岚,王勇德,张健.血清抵抗素与冠状动脉粥样硬化的关系[J].天津医药,2007,35(7):506-508. 被引量：5
  • 3张望,张健.炎症标志物抵抗素研究进展[J].动物医学进展,2007,28(5):88-90. 被引量：7
  • 4Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment:prospective meta-analysis of data from 90,056 partici- pants in 14 randomised trials of stafins, Lancet,2005,366:1267-1278.
  • 5Amarenco P, Bogousslavsky J, Callahan A, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med, 2006,355 : 549- 559.
  • 6Alfon J, Guasch JF, Berrozpe M, et al. Nitric oxide synthase Ⅱ ( NOS Ⅱ ) gene expression correlates with at herosclerotic intimal thickening. Pre- ventive effects of HMG-COA reductas inhibitors. Atheroscler asis, 1999, 145:325-331.
  • 7Brown BG, Zhao XQ. Importance of endothelial function in mediating the benefits of lipid-low erring therapy. Am J eardiol, 1998,82:49-52.

二级参考文献22

  • 1Steppan C M,Bailley S T,Bhat S,et al.The hormone resistin links obesity to diabetes[J].Nature,2001,409:307-312.
  • 2Vozarovade C B,Degawa Y M,Considine R V,et al.High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima indians[J].Diabetes,2004,53:1279-1284.
  • 3Lee J H,Chan J L,Yiannakouris N,et al.Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration:cross-sectional and interventional studies in normal,insulin-resistant,and diabetic subjects[J].J Clin Endocrinol Metab,2003,88:4848-4856.
  • 4Stejskal D,Adamovska S,Bartek J,et al.Resistin:concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2003,147:63-69.
  • 5Bokarewa M,Nagaev I,Dahlberg L,et al.Resistin,an adipokine with potent pro-inflammatory properties[J].J Immunol,2005,174:5789-5795.
  • 6Reilly M P,Lehrke M,Wolfe M L,et al.Resistin is an inflammatory marker of atherosclerosis in humans[J].Circulation,2005,111:932-939.
  • 7Daghri A N,Chetty R,Ternan P G,et al.Serum resistin is associated with C-reactive protein and LDL cholesterol in type 2 diabetes and coronary artery disease in a Saudi population[J].Cardiovasc Diabetol,2005,4:10.
  • 8Kaser S,Kaser A,Sandhofer A,et al.Resistin messengerRNA expression is increased by proinflammatory cytokines in vitro[J].Biochem Biophys Res Commun,2003,309:286-290.
  • 9Shojima N,Sakoda H,Ogihara T,et al.Humoral regulation of resistin expression in 313-L1 an d mouse adipose cells[J].Diabetes,2002,51:1737-1744.
  • 10Bokarewa M,Nagaev I,Dahlberg I,et al.Resistin,an adipokine with potent proinflammatory properties[J].The Journal of Immunology,2005,18:5789-5795.

共引文献9

同被引文献47

引证文献6

二级引证文献28

河北医药
2011年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部