摘要
目的研究短暂性脑缺血发作患者血清抵抗素水平的变化,及其与纤维蛋白原的关系,探讨其在短暂性脑缺血发作中的病理生理意义。方法短暂性脑缺血发作实验组、对照组取血,测定空腹血糖、血脂、胰岛素、纤维蛋白原水平,ELISA方法测定血清抵抗素水平。结果短暂性脑缺血发作组与正常对照组相比,血清抵抗素水平升高(P<0.05)。多元logistic回归分析显示,血清抵抗素为短暂性脑缺血发作的独立危险因素,并与TIA病变程度呈正相关。抵抗素与纤维蛋白原水平呈正相关。结论抵抗素为短暂性脑缺血发作的独立危险因素,通过影响凝血系统参与短暂性脑缺血发作的病理生理过程,可用于评价病情严重程度,可作为缺血性脑血管病预防的新靶点。
Objective To investigate the effects of serum resistin levels in transient ischemic attack. Methods Concentrations of blood sugar, lipid, insulin and fibrinogen were determined in patients with transient ischemic attack and normal controls, and also serum Resistin level was determined by ELISA. Results The serum Resistin level was higher in patients with transient ischemic attack than in normal controls （ P 〈 0.05）. Resistin positively related to the severity of transient ischemic attack and the level of fibrinogen. Conclusions Resistin may be an important target to reduce risks of cerebrovascular disease and participates in the progress of transient ischemic attack probably by effecting coagulation.
出处
《山东大学学报（医学版）》
CAS
北大核心
2008年第5期510-512,共3页
Journal of Shandong University:Health Sciences
