摘要
目的:了解我院药品不良反应(ADR)发生特点及引发的相关因素,促进临床安全合理用药。方法:对我院2010年1月1日～12月31日收集的183例ADR报告分别从患者性别和年龄、药品种类和剂型、ADR累及的器官或系统及临床表现等方面进行分类统计分析。结果:183例ADR中,男性比例略高于女性,50岁以上人群发生率最高;涉及的药品有58种,抗肿瘤药居首位(57例,31.5%),其次为抗菌药物(47例,25.68%)及中药注射剂(42例,22.95%);注射剂引起的例数最多;临床表现以血液及造血系统损害(26.19%)、中枢及外周神经系统损害(24.39%)皮肤及附件损害(23.81%)较常见。结论:应重视ADR的监测和报告工作,避免或减少ADR重复发生;合理使用抗菌药物及中成药制剂;合理选择给药途径,尽量采用口服给药,确保临床安全、合理用药。
Objective：To undrestand the characteristics of adverse drug reactions（ADR） and the related tactors initiating the occurrence for their rational use in clinic.Methods：183 cases of ADR were collected from Jan 1.2010 to Dec 31.2010,which Were analyzed in respect of the patient, s age and sex,drug species,failed organs and clinical manifestation .Results：Among the 183 cases,male cases outnumbered the female cases,and ADRs occurred most frequently among the group over 50;ADRs were mainly caused by 58 kinds of drugs,of which anticancer agents occupied the first place（57cases,31.15%）,and then anti-infective agents （47 cases,25.68%）,traditionat Chianese Medicin（42cases,22.95%）;ADRs were chiefly induced by intravenous administration;Clinical manifestation mainly included damage to the hematiopoietic system（26.19%）,the nerve system（24.39%）,skin and appendixes（23,81%）.Conclusion：hnportanee should be attached to teh monitiorng and reporting of ADRs to avoid the repeated occurrence;Anti-infective agents and traditional Chinese Medicine should be used rationally ,More reasonable route of admininistration should be choosed to ensure medication safety and rational drug use.
出处
《中国医药导刊》
2011年第7期1246-1247,共2页
Chinese Journal of Medicinal Guide
关键词
药品不良反应
用药监测
分析
用药安全
Adverse cling reaetioni
Monitoring of clinical
drug useg
Analysis
Medication safety
