摘要
目的:比较新诊断精神分裂症患者与非精神分裂症患者不同服药周期内发生糖代谢异常的差异性。方法:选取24例在本院新诊断精神分裂症患者以及33例非精神分裂症患者进行糖尿病流行病学调查,于实验开始前、服药1、3个月、1、2.5年时,分别测定两组患者的空腹血糖(Glu0)、胰岛素水平(Ins0),服用75g葡萄糖粉后2h血糖(Glu120)、胰岛素水平(Ins120);进一步分析了精神分裂症患者发生糖代谢异常与性别、年龄、肥胖、服药情况之间的相关性。结果:24例精神分裂症患者中,入组时即有胰岛素分泌异常,服药1个月时既有糖代谢异常患者出现,糖代谢异常随服药时间的推进增加,至服药2.5年时发生糖代谢异常9例(37.5%),胰岛素分泌异常11例(45.8%)。诊断糖尿病7例(29.2%)明显高于非精神分裂症患者组。精神分裂症患者糖代谢发生的风险与年龄、腹型肥胖有很大相关性。结论:精神分裂症患者有糖代谢异常现象发生,并随服药时间的推进增加;年龄和体重是其发生糖代谢异常的可能风险因素。
Objective：To analysis the difference of glucose metabolism abnormal of newly diagnosed schizophrenics and non-occurrence of schizophrenia in different observation period,and the possible factors.Methods：Selected the 24 eases newly diagnosed schizophrenia patients with the course of 2.5 years and 33 patients with non-psychiatric in our hospital todo epidemiological investigation ofdiabetes patients, and measured fasting blood glucose,insulin,postprandial 2 h blood glucose and insulin before the test start, and after the experi- ment of one month,three months,one year. two and a half year.Further, the correlation between abnormal glucose metabolism in patients and gender, age.the medication conditions and obesity were analyzed.Results：There was glucose metabolism abnormal at the start. Atfter one month of the experiment in 24 patients with chronic schizophrenia, it had been increased of abnormal glucose metabolism and diabetes with the over time.At the end of the experiment,there were 9 eases of diabetes（37.5%） and 11 cases of insulin secreted abnormal（45.8%）in the schizophrenia group.the of diabetes diagnosed definitely were 7 ease（29.2%）It was more than schizophrenic patient group significant. It was relevant between the risk glucose metabolism in patients with schizophrenia with age,abdominal obesity.Conclusion：There was the abnormal glucose metabolism risk in the early onset of schizophrenia.After 3 months taking the drug,the proportion of abnormal glucose metabolism increased sharply,and gradually increasede over time.It was possible risk factors that the age and weight abnormal.
出处
《中国医药导刊》
2011年第7期1164-1166,共3页
Chinese Journal of Medicinal Guide
关键词
精神分裂症
糖尿病
糖代谢异常
危险因素
Schizophrenia
Diabetes
Abnormal glucose metabolism
Risk factors
