摘要
目的:探讨育龄妇女EP组织内VEGF、CD34和INS的表达及其与EP发生的关系。方法:免疫组化SP法观察50例EP组织中VEGF、CD34和INS的表达。结果:EP组织腺上皮VEGF表达明显增强(P<0.01),MVD值明显增高,INS表达与正常子宫内膜相比无差异(P>0.05)。EP组织MVD值与VEGF表达呈正相关(r=0.813 2),而VEGF的表达强度与INS表达无明显相关关系(r=-0.179 7)。结论:VEGF与EP的发生有关,VEGF促进EP组织内的血管生成。EP组织中INS表达与正常子宫内膜无差异,目前未提示INS与EP发病的相关性。
Objective：To explore the expressions of vascular endothelial growth factor（VEGF）,CD34 and insulin in endometrial polyps of women of childbearing age and their relationships with the occurrence of endometrial polyps. Methods：Immunohistochemical SP method was used to detect the expression levels of VEGF,CD34 and insulin in 50 cases with endometrial polyps. Results：In glandular epithelium of endometrial polyps,the expression of VEGF increased significantly（P0.01）,MVD value increased significantly,there was no significant difference in the expression level of insulin between glandular epithelium of endometrial polyps and normal endometrium（P0.05）.In endometrial polyps,there was positive correlation between MVD value and VEGF expression（γ=0.813 2）,but there was no apparent correlation between expression level of VEGF and insulin expression（γ=-0.179 7）. Conclusion：VEGF is related to the occurrence of endometrial polyps,which can promote angiogenesis of endometrial polyps.There is no significant difference in the expression level of insulin between endometrial polyps and normal endometrium,it is indicated that there is no correlation between insulin and onset of endometrial polyps at present.
出处
《中国妇幼保健》
CAS
北大核心
2011年第30期4773-4775,共3页
Maternal and Child Health Care of China
