摘要
给BALB/C系小鼠经口染毒铅或锌的无离子水溶液16周后,测定了小鼠末梢血红细胞σ-氨基酮戊酸脱水酶(σ-ALAD)活性和脾脏淋巴细胞对植物血凝索和刀豆素刺激的增殖反应。结果表明,铅接触组的未梢血红细胞σ-ALAD活性和脾脏植物血凝素和刀豆素所致T淋巴细胞增殖反应明显地低于对照组(P<0.05),而15.2mmol/L锌能拮抗2.4mmol/L铅抑制σ-ALAD活性和脾脏刀豆素所致T淋巴细胞增殖反应。
The activity of delta-aminolevulinic acid dehydratase (delta-ALAD) of the erythrocytes in mice and the immune responsiveness of BALB/C mice given lead and/or zinc in their drinking water for 16 weeks weredetermined. The result shows that lead significantly suppresses the activity of delta-ALAD of erythrocytes in mice and the responses of splenic T lymphocytes to phytohemagglutinin(PHA)and concanavalin A(Con A). Furthermore, zinc(15.2mmol/L)effectively protects against the lead (2.4mmol/L)induced inhibition of the activity of delta-ALAD of erythrocytes in mice and against the hyperplastic response of splenic T lymphocytes to Con A.
出处
《延边医学院学报》
CAS
1990年第2期92-96,共5页
Journal of Medical Science Yanbian University
关键词
铅
锌
免疫细胞
中毒
lead
zinc
immunity
cellular
toxicology
aminole-vulinic acid dehydratase
