摘要
目的了解营养素锌(Zn)、硒(Se)和维生素C对小鼠短期铅(Pb)、镉(Cd)、汞(Hg)染毒的体内分布的影响,观察其对Pb、Cd、Hg联合损害的拮抗作用。方法染毒组小鼠灌胃给予Pb(7mg/kg)、Cd(1mg/kg)和Hg(0.7mg/kg),处理组除给予Pb、Cd、Hg染毒外,同日或次日给予Zn、Se或维生素C,剂量为Zn12.5mg/kg或62.5mg/kg,Se40μg/kg或200μg/kg,维生素C80mg/kg或400mg/kg。连续处理3次。结果3种营养素都能促进毒物从粪中排出;可减少心脏中Cd含量(P<0.05);给予营养素可使由染毒引起的肝脏器系数、肾脏器系数和脾脏器系数增大幅度降低。但是加营养素组的肝和肾中Pb、Cd、Hg含量都较染毒组高,体重增长与染毒组亦没有差异。连续染毒引起动物体重下降而隔日染毒对动物体重没有明显影响。营养素拮抗效果以加Se组最好,高Se组优于低Se组,而高维生素C和高Zn组并不优于相应的低剂量组。结论Zn、Se和维生素C对Pb、Cd、Hg联合损害有明确的拮抗作用,但可引起毒物在肝、肾中的含量增加,对体重无影响,表明在此染毒剂量下,Zn、Se和维生素C的拮抗能力是有限的。
Objective To observe the extent of antagonistic action of nutrients Zn, Se and vitamin C to heavy metal Pb, Cd and Hg, and their distribution in mice. Methods Pb （7 mg/kg）, Cd （1 mg/kg） and Hg （0.7 mg/kg） were orally instilled in mice and at the same day or the next Zn （12.5 mg/kg or 6 2.5 mg/kg）, Se （40 μg/kg or 200 μg/kg） and vitamin C （80 mg/kg or 400 mg/kg） were distilled successively for 3 times. Results These nutrients could promote the increase of excrefion of Pb, Cd and Hg in feces, and decreased the level of Cd in heart （P〈0.05）. However, the levels of Pb, Cd and Hg in liver and kidney of nutrient groups were higher than exposed groups, and the difference in body weight was also not significant. These nutrients could not reduce the loss of body weight after continuously administration of these metals and giving nutrients next day for 3 times. The antagonistic action of Se was the best, high dose was better than low dose. High dose of Zn or vitamin C was not better than the low dose. Conclusions The antagonistic action of these nutrients was rather limited.
出处
《工业卫生与职业病》
CAS
CSCD
北大核心
2005年第5期305-309,共5页
Industrial Health and Occupational Diseases
