摘要
目的探讨纤维结合蛋白(FN)复方制剂对创伤愈合的促进作用。方法建立小鼠全皮层创伤修复模型,随机分为生理盐水组、胶原蛋白溶液治疗组、HA溶液治疗组、FN溶液治疗组、FN复方制剂治疗组、阳性对照治疗组,通过观察创面愈合情况、测定创面愈合率,采取皮肤组织学标本进行HE染色及免疫组化染色,观察各组药物对创伤愈合的促进作用。结果各治疗组药物均能促进创伤愈合,FN复方制剂治疗组疗效最佳。结论 FN复方制剂促进创伤愈合的作用优于单一成分。
OBJECTIVE To evaluate the effect of Compound fibronectin（FN） on wound healing.METHODS The skin wound model rats were divided randomly into six groups：normal saline group,collagen group,hyaluronic acid（HA） group,FN group,Compound FN group,positive control group.The wound healing effect was evaluated by measuring,wound healing rate and HE staining and immunohistochemical staining for skin tissue specimens.RESULTS Compared with normal saline group,all treatment groups could promote skin wound healing observably,and Compound FN group showed the best therapeutic effect.CONCLUSION Compound FN showed a better effect on wound healing than single composition.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2011年第5期463-465,共3页
West China Journal of Pharmaceutical Sciences
