摘要
目的研究复方苦参注射液联合适形调强放疗（IMRT）治疗局部晚期鼻咽癌的疗效和患者不良反应。方法对2006年3月至2009年3月96例局部晚期鼻咽癌患者行前瞻性研究，抽签法随机分成复方苦参注射液联合放疗组（治疗组）48例和单纯放疗组（对照组）48例。放射治疗鼻咽部6～8周总剂量：（66～78）Gy／（30～39）次；颈部淋巴结6～8周总剂量：（60～70）Gy／（30—35）次；颈部每5．5～6周预防剂量：（50～54）Gy。治疗组自放疗开始至结束，每天予5％葡萄糖注射液加复方苦参注射液20ml静脉滴注。结果治疗组和对照组鼻咽部病灶有效率分别为93．8％（45／48）和79．2％（38／48），颈部转移淋巴结有效率分别为91．7％（44／48）和75．0％（36／48），两组比较差异均有统计学意义（均P〈0．05）。治疗组口腔黏膜损伤及皮肤损伤程度明显低于对照组（均P〈0．01）。结论复方苦参注射液联合IMRT治疗局部晚期鼻咽癌可提高放疗疗率，减轻放疗不良反应，值得临床推广。
Objective To detect the efficacy of compound matrine combined with intensity modulated radiotherapy （IMRT） for patients with locally advanced nasopharyngeal carcinoma （NPC）. Methods A total of 96 patients with locally advanced NPC were randomized into compound matrine combined with IMRT group （the therapeutic group） （n =48） and IMRT group （control group） （n =48）. The nasopharyngeal DT and lymph nodes DT were 66-78 Gy/（33-39 f） in 6-8 weeks, 60-70 Gy/（30-35 f） in 6-8 weeks, respectively. The prophylactic dose of neck was 50-54 Gy. Results The NPC efficacy of the therapeutic group was 93.8 % （45/48） and control group was 79.2 % （38/48）. There was significant difference between the two groups in curative effect （P 〈0.05）. The lymph nodes efficacy of the therapeutic group was 87.5 % （44/48） and control group was 75.0 % （30/48）. There was significant difference between the two groups in curative effect （P 〈0.05）. The side effects of mucosa were fewer in therapeutic group while the infection rate of pharynx oralis was higher in control group （P 〈0.01）. Conclusion Compound matrine combined injection can improve short- term curative effect of IMRT of locally advanced NPC and significantly decreased side effect of radiotherapy.
出处
《肿瘤研究与临床》
CAS
2011年第9期623-625,共3页
Cancer Research and Clinic
关键词
苦参
放射疗法
计算机辅助
鼻咽肿瘤
SOPHORA FLAVESCENS
Radiotherapy, computer-assisted
Nasopharyngealneoplasms
