摘要
目的观察骨化三醇对老年男性骨质疏松患者骨量的改善情况以及用药前后平衡状况的改善情况。方法随机选择就诊于陕西省人民医院老年病门诊的男性骨质疏松患者48例,用简单随机化的方法将研究对象分为试验组与对照组,实验组26例给予口服骨化三醇胶丸0.25μg,2次/d,元素钙600 mg/d;对照组22例只给予元素钙600 mg/d,连续治疗6个月,观察治疗后患者骨量及平衡状况改善情况。研究结果比较采用两独立样本均数的t检验。结果治疗前后,实验组L2、L4、股骨颈骨密度T值及平衡功能与对照组相比均有显著差异(P<0.05),L2-4、L3、大转子及words三角骨密度T值与对照组相比差异无显著性(P>0.05)。结论骨化三醇可以有效改善骨量,尤其在增强腰椎骨量方面具有显著意义,而且对协调平衡也有很好的帮助。
Objective To observe the improvement of bone mass and balance ability of elderly male osteoporosis patients treated with calcitriol. Methods Forty-eight elderly male osteoporosis patients in Shaanxi Provincial People＇s Hospital were selected. They were randomly divided into experimental group and control group. Patients in experimental group （26 cases） were treated with 0.25 μg calcitriol twice a day and 600 mg calcium once a day. Patients in control group （22 cases） were only treated with 600mg once a day. The treatment continued for 6 months. The improvement of bone mass and balance ability after the treatment was observed. The results were analyzed using two-sample t-test of the mean. Results Compared with the control group, BMD T values of L2, L4, and the femoral neck were significantly different experimental group before and after the treatment （ P 〈 0. 05 ）. BMD T values of L2-4, L3, and the Ward＇s triangle were not significantly different between experimental group and control group （ P 〉 0. 05 ）. Conclusion Calcitriol can effectively improve bone mass, especially the bone mass in lumbar vertebra, and help to increase the ability of balance.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第9期821-823,共3页
Chinese Journal of Osteoporosis
关键词
骨化三醇
老年男性
骨质疏松
临床研究
Calcitriol
Elderly males
Osteoporosis
Clinical controlled trial
