摘要
目的：研究川芎嗪对博莱霉素致肺间质纤维化大鼠端粒酶表达的影响。方法：SD雄性大鼠随机分为正常组、模型组、阳性药物对照组及川芎嗪组。分别于给药14、28d后取肺组织，冷冻切片，原位杂交法检测端粒酶的表达。结果：与模型组相比，川芎嗪在14d和28d均可下调端粒酶的表达，而且川芎嗪组端粒酶的表达14d较28d高。结论：川芎嗪通过抑制端粒酶的活性，对特发性肺纤维化起到防治作用。
Objective： To study the effect of tetramethylpyrazine （TMP） on the expression of telomerase in bleomycin-induced pulmonary fibrosis rats. Methods： SD rats were randomly divided into a normal group, a model group, a positive control group and a TMP group. After they were given the medicine,the rats were killed on 14 and 28 days to get lung tissues for in situ hybridization studies of telomerase. Results： Compared with the model group, TMP restrained the expression of telomerase on 14 and 28 days, and the expression of telomerase on 14 days was more than 28 days. Conclusion： TMP has the function of anti-fibrosis of the lung through restraining the expression of telomerase.
出处
《解剖学杂志》
CAS
CSCD
北大核心
2011年第4期443-445,F0004,共4页
Chinese Journal of Anatomy
基金
河北省人力资源和社会保障厅资助项目（20100306）
河北省科技攻关课题（20042761459）
河北省保定市科技局资助课题（04F001（4））
关键词
川芎嗪
肺间质纤维化
端粒酶
原位杂交
tetramethylpyrazine
pulmonary fibrosis
telomerase
in situ hybridization
