摘要
内质网应激是细胞内一种适应性机制,持续或过强的内质网应激则诱导细胞凋亡,造成组织损伤。多项研究显示内质网应激是多种心血管疾病如动脉粥样硬化、缺血性心脏病、心肌肥大、心力衰竭及糖尿病心肌病等发生、发展的共同通路,干预内质网应激可能成为心血管疾病治疗的新靶点。
Endoplasmic reticulum（ER） stress is initially aimed at compensating for damage but can eventually trigger cell apoptosis if ER dysfunction is severe or prolonged.Plenty of evidence shows that ER stress-induced apoptosis is involved in the pathogenesis and development of many cardiovascular diseases,such as atherosclerosis,ischemic heart disease,myocardial hypertrophy,heart failure,diabetic cardiomyopathy,and so on.Therefore,intervention of ER stress may provide a potential target for treating cardiovascular diseases.
出处
《国际病理科学与临床杂志》
CAS
2011年第4期305-309,共5页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金(81070130)~~
关键词
内质网应激
未折叠蛋白反应
细胞凋亡
心血管疾病
endoplasmic reticulum stress
unfolded protein response
apoptosis
cardiovascular diseases
