摘要
目的探讨原发性肝癌切除术后肝动脉化疗栓塞(TACE)的疗效。方法将86例肝癌术后的高危复发患者分为干预组(TACE治疗组)和对照组(未行TACE治疗组)。术后高危复发的标准为:①单发病灶>5cm;②病灶数≥2处;③术后病理检查有镜下癌栓。符合其中任意一条为术后高危复发患者。干预组术后1～2月行TACE治疗。结果术后12个月内干预组复发率为32.43%,对照组为17.95%,干预组高于对照组;24个月总体复发率干预组为48.94%,对照组为48.72%,两组相当,差异无统计学意义(P=0.8224)。干预组中位生存期26个月;对照组中位生存期22个月;两组比较差异有统计学意义(P=0.0498)。结论原发性肝癌外科切除术后,对高危复发患者行TACE治疗能使肝内残留灶早发现、早治疗,是延长生存期的有效治疗方法之一,但并不能降低术后复发率。
Objective To explore the effect of postoperative transarterial chemoemblization （TACE） on recurrence of high-risk patients after resection of hepatocellular carcinoma. Methods Eighty-six high-risk patients after surgical resection of hepatocellular carcinoma were divided into TACE group and control group. Forty-seven patients in TACE group received TACE 1 ～ 2 months after resection, the other 39 patients in control group were treated without TACE. The high-risk factors were defined as single tumor 5 cm or tumor nodules ≥2 or with the presence of microscopic tumor thrombus. Results Recurrent rate of TACE group was higher than that of control group at 12 th month post-resection（32.43% vs 17.95%, P〈0.05）, but there was no significant difference on recurrent rates between two groups at 24th month post-resection （48.94% vs 48.72%, P = 0.8224）.The median survival time was 26 months in TACE group which was comparable to 22 months in control group （P = 0.0498）. Conclusion Postoperative TACE has no effect on recurrence, but may be of benefit to detect residual tumor and prolong the median survival time.
出处
《现代消化及介入诊疗》
2011年第4期239-241,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
关键词
肝癌
肝动脉化疗栓塞
治疗
Hepatoccllular carcinoma
Transarterial chemoembolization
Therapy
