摘要
目的探讨肝动脉化疗栓塞术治疗肝恶性肿瘤对肝功能的影响。方法选取2010年8月—2012年10月收治的肝恶性肿瘤患者共80例,分析肝动脉化疗栓塞术前后患者肝功能的变化规律。结果与术前1周比较,术后1 d天冬氨酸氨基转氨酶(AST)、谷氨酸氨基转氨酶(ALT)、直接胆红素(DBIL)及总胆红素(TBIL)均明显升高(P<0.05),术后1周ALT、DBIL及TBIL均明显升高,差异均有统计学意义(P<0.05)。术前1周与术后4～6周患者的Child-Pugh分级A、B级及Child评分差异均有统计学意义(P<0.05)。肝恶性肿瘤患者的肝功能变化与治疗次数、是否合并肝硬化及门脉癌栓相关(P<0.05)。结论肝癌患者在初次肝动脉化疗栓塞术后的肝功能损害是短期的,于30 d左右即可恢复至术前水平。
Objective To investigate the effect of transcatheter arterial chemoembolization（TACE） on liver function of patients with liver cancer.Methods Eighty patients with liver cancer from Aug 2010 to Oct 2012 were divided and analyzed the change of liver function before and after TACE.Results The indexes of AST,ALT,DBIL and TBIL one day after TACE were obviously higher than before procedure（P〈0.05）.The indexes of ALT,DBIL and TBIL one week after TACE were obviously higher than before（P〈0.05 ）.Child-push grade and score one week before TACE and 4-6 weeks after TACE had no significance（P〈0.05）.The change of liver function was related to number of treatment,cirrhosis and portal vein thrombus（P〈0.05）.Conclusion Most patients of liver cancer has short term Liver function damage,but can recover to the level of TACE before within 30 days.
出处
《疑难病杂志》
CAS
2013年第7期516-518,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
肝动脉化疗栓塞术
肝癌
肝功能
CHILD-PUGH分级
Transcatheter arterial chemoembolization
Liver malignant tumor
Liver function
Child-Pugh grade
