摘要
目的:了解我院抗菌药不良反应/事件(ADR/ADE)发生的一般规律及特点,为临床合理用药提供参考。方法:对我院2005年1月～2009年12月收集的407例抗菌药引起的ADR/ADE报告表进行统计分析。结果:407例ADR/ADE报告中,ADR 362例(88.94%),ADE 45例(11.06%),涉及抗菌药36个品种,其中以头孢菌素类构成比最高(41.28%),其次为青霉素类(21.87%)和喹诺酮类(14.50%);ADR/ADE的临床表现主要为皮肤及附件损害(63.49%);构成比前5位药品为左氧氟沙星,头孢噻肟,克林霉素,阿奇霉素,阿洛西林;严重ADR/ADE构成比为4.42%,无死亡病例。结论:抗菌药引发ADR/ADE与多种因素有关,应加强抗菌药的合理使用,提高医护人员对ADR/ADE的警惕性与监测水平,以保证用药安全性与合理性。
Objective： To study the general rules and characteristics of adverse drug reaction/events （ADR/ADE） caused by matibacterial drugs in order to improve the rational drug use level in clinic. Method： A total of 407 reports of adverse reactions/events caused by antibacterial drugs in our hospital from January 2005 to December 2009 were collected and statistically analyzed. Result：407 cases of reaction/event reports including 362 cases of ADR （88.94%） and 45 cases of ADE （ 11.06% ） were involved in 36 varieties of antibacterial drugs with cephalosporins （41.28%） leading the list, and followed by penicillins （21.87%） and quinolones （ 14.50% ）. The main clinical manifestations of adverse drug reaction/ events were lesions of skin and accessories（63.49% ）, the top five producers were levofloxacin, cefotaxime, clindamycin, azithromycin and azlocillin. Severe adverse drug reaction/events rate was 4.42%, and no death occurred. Conclusion：The adverse drug reaction/events caused by antibacterial drugs were closely associated with various factors; therefore, a rational antibacterial drug use should be strengthened, and health care providers should maintain high vigilance against ADR/ADE and improve the monitoring level of ADR/ADE.
出处
《药物流行病学杂志》
CAS
2011年第7期344-347,共4页
Chinese Journal of Pharmacoepidemiology
关键词
抗菌药
药品不良反应
合理用药
药品不良事件
Antibacterial drugs
Adverse drug reactions （ADR）
Rational drug use
Adverse drug events （ADE）
