摘要
目的总结Survivin基因在肿瘤中的作用。方法通过复习国内、外文献,回顾分析survivin的生物学特性及其在肿瘤基因治疗与临床应用中的研究现状。结果 survivin基因是迄今为止发现的最强的凋亡抑制基因,主要是通过直接抑制caspase级联反应下游的终末子caspase-3和caspase-7的活性,从而发挥抗凋亡作用;sur-vivin基因可通过加快肿瘤细胞由G1→S期的转换以及使肿瘤细胞在G2/M期逃避对凋亡的识别而促进肿瘤细胞增殖、分化;survivin基因能通过血管形成因子(VEGF、bFGF、Ang-1和COX-2)在血管形成的中间环节发挥重要作用。结论 Survivin可抑制肿瘤细胞的凋亡、促进肿瘤细胞增殖分化和肿瘤血管生成,提示其可能作为一种新的肿瘤标志物,成为检测恶性肿瘤的指标。
Objective To summarize the role of survivin gene in tumor.Methods The research status on biological characteristics the role of survivin gene in tumor for gene therapy and clinical application was retrospectively analyzed after related domestic and foreign literatures were reviewed.Results Survivin gene was by far found to be the best powerful apoptosis inhibition gene,which played anti-apoptosis role mainly through inhibiting directly the activity of caspase-3 and caspase-7 in the downstream of cascade reaction.Survivin gene promoted tumor cell proliferation and differentiation through speeding up tumor cells transition of G1→S phase and eluding the recognition of tumor cells to the apoptosis in G2/M phase.Survivin gene played important role in the intermediate links of vasiformation through angiogenic factor（VEGF,bFGF,Ang-1,and COX-2）.Conclusion Survivin gene may inhibit the apoptosis,promote the proliferation and differentiation of tumor cells and tumor angiogenesis,suggested that survivin gene has potential to act as a novel tumor marker and become an indicator of malignant tumor.
出处
《中国普外基础与临床杂志》
CAS
2011年第7期779-782,共4页
Chinese Journal of Bases and Clinics In General Surgery
