摘要
目的探讨卵巢上皮性肿瘤中Ki-67抗原和Survivin的表达及其相关性。方法用免疫组织化学技术二步法检测47例上皮性卵巢癌和24例良性上皮性卵巢肿瘤中Ki-67抗原和Survivin的表达。结果Ki-67阳性染色位于细胞核,良性肿瘤中Ki-67指数为0.17±0.20,显著低于恶性的19.59±16.48(P<0.01)。Survivin在良性卵巢肿瘤中的表达率为33.33%,显著低于恶性的70.21%(P<0.01)。Ki-67和Survivin在上皮性卵巢癌中的表达均与组织学类型无关,而与临床分期及病理学分级密切相关(P<0.01)。Ki-67和Survivin的表达有相关性。结论Ki-67和Sur-vivin基因在卵巢癌中表达增强且相关。
Objective To investigate the expression of Ki-67 antigen and Survivin in epithelial ovarian tumor and their relationship.Methods Immunohistochemical assay SP method）was used to examine the expression of Ki-67 antigen and Survivin in 24 cases of benign and 47 cases of malignant epithelial ovarian tumor. Results The staining reaction of Ki-67 was mainly confined to the cellular nucleus. Ki-67 index in malignant tumor（ 19.59 ±16.48） was significantly higher than that in benign epithelial ovarian tumor（0.17 ±0.20）（ P 〈 0.01 ）. The positive rate of Survivin in the malignant group was 70.21%, significantly higher than those in the benign group（33.33% ） .The expression of Ki-67 and Survivin was correlated with clinical stage and pathologic grade （ P 〈 0.01 ）, but not with tumor type. There was a close correlation between Ki-67 and Survivin. Conclusion The expression of Ki-67 antigen and Survivin enhanced in epithelial ovarian tumor. There was a positive correlation between Ki-67 and Survivin expression.
出处
《基础医学与临床》
CSCD
北大核心
2006年第3期312-314,共3页
Basic and Clinical Medicine
