摘要
目前有关创伤后应激障碍(PTSD)及其发病机制的研究很多,但遗传因素对其影响尚不清楚。PTSD的遗传学研究尚处于起步阶段,研究的数量较少,且多停留在单个基因、单个位点的多态分析。由于PTSD本身在临床上具有高度异质性,应结合表观遗传学与传统遗传学两种研究方法,从PTSD的遗传易感性与环境的相互作用方面探讨其发病机制。本文就PTSD的遗传易感性及相关易感基因进行综述,并对有关研究方法进行了分析。
Although extensive research has already been done on the mechanism of posttraumatic stress disorder（PTSD）,little is known about genetic influences on PTSD.Genetic studies in PTSD are still in its infancy,which was focusing on the polymorphism analysis of the individual genes and single locus.Because the clinical pictures of PTSD are complex,to explore the mechanism of diseases about the interaction of gene and environment,the genetic research on PTSD should be carried in combination with epigenetics and classic genetics.Molecular genetic studies on susceptibility to PTSD reported in literature and the related methods were reviewed.
出处
《中国临床神经科学》
2011年第4期433-437,444,共6页
Chinese Journal of Clinical Neurosciences
基金
全军医药卫生科研基金课题(编号:08G096)
关键词
创伤后应激障碍
基因多态性
遗传易感性
posttraumatic stress disorder
gene polymorphisms
genetic susceptibility
