摘要
探讨左旋精氨酸（Ｌ－Ａｒｇ）在大鼠急性水肿性胰腺炎（ＡＥＰ）中的作用。方法观察倍数剂量Ｌ－Ａｒｇ治疗ＡＥＰ大鼠后，血浆和胰组织一氧化氮（ＮＯ）浓度、血浆淀粉酶、平均动脉压（ＭＡＰ）、胰组织病理的变化。结果ＡＥＰ大鼠血浆、胰组织ＮＯ浓度明显降低，Ｌ－Ａｒｇ５０、１００ｍｇ／ｋｇ升高血浆、胰组织ＮＯ浓度，改善了大鼠ＡＥＰ；Ｌ－Ａｒｇ８００、１６００ｍｇ／ｋｇ体重使ＮＯ浓度过度升高，加重ＡＥＰ成为急性出血坏死性胰腺炎（ＡＨＮＰ）；胰组织病理评分与血浆、胰组织ＮＯ浓度呈正相关。Ｌ－Ａｒｇ对ＭＡＰ的影响较小。血浆淀粉酶除８００ｍｇ／ｋｇ体重组明显降低外，其余各组间无明显差异。结论Ｌ－Ａｒｇ因升高ＮＯ浓度而参与了大鼠ＡＥＰ的病理过程。
Objective To investigate the role of different doses of L-arginine in the treatment ofacute edematous pancreatitis in rat. Method The alterations of mean arterial pressure (MAP), serumamylase, nitric oxide in serum and pancreatic tissue, pancreatic pathohistology were studied. ResultContent of nitric oxide in serum and pancreatic tissue was correlated with the scores of pancreatic pathohistology significantly (r1=0. 48, r2=0. 63, P<0. 05). MAP was decreased and serum amylase increased, but didn't relate to the scores of pancreatic pathohistology. Conclusion L-arginine might beinvolved in the development of acute pancreatitis by increasing the content of nitric oxide.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第2期161-163,共3页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金
关键词
急性
胰腺炎
平均动脉压
左旋精氨酸
一氧化氮
Acute pancreatitis, Mean arterial pressure, L-arginine ,Nitric oxide
