摘要
目的 以自发性高血压大鼠 (SHR)为研究对象 ,观察血管紧张素Ⅱ (AngⅡ )受体AT1阻滞剂缬沙坦的降压作用和对血液及组织AngⅡ浓度的影响 ,探讨左室重塑与心肌AngⅡ水平的关系。方法 将雄性 15周龄SHR分两组(n=6) ,缬沙坦 3 0mg·kg-1·d-1,对照组用等量蒸馏水灌胃。用高压液相放免法 (HPLC RIA)测定治疗 4周前后SHR血液、肾脏、心脏和动脉壁中AngⅡ浓度。结果 治疗组血压由 (2 0 5 0±10 7)mmHg下降到 (15 0 0±6 8)mmHg(P <0 .0 1) ,左室重量/体重由 (2 64 3±17 1)mg/ 10 0g下降到(2 0 8 2±13 9)mg/ 10 0g(P <0 .0 1) ,左室心肌和动脉壁的AngⅡ水平相应降低(P <0 .0 1) ,但血液和肾脏中AngⅡ水平上升 (P <0 .0 1)。结论 缬沙坦抑制左室重塑与在AT1受体水平上阻滞AngⅡ和降低心肌组织AngⅡ含量有关。
Objective To study the relationship between left ventricular remodeling and tissue angiotensinⅡ (AngⅡ) content based on the observation of effects of the specific antagonist of AT 1 receptor valsartan on blood pressure and AngⅡ levels in blood and tissues of spontaneously hypertensive rats(SHR). Methods Valsartan (30 mg·kg -1 ·d -1 ) and equal volume of distilled water were adminstered to 15 week old male SHRs of the experimental ( n =6) and control groups ( n =6) respevtive ly for 4 weeks by gavage. High performance liquid chromatography based radioimmunoassays (HPLC RIA) was used to measure AngⅡ levels in plasma, kidney, left ventricle, and artery. Results Four weeks′ treatment with valsartan on SHR lowered the blood pressure from 205.0± 10.7 mm Hg to 150.0±6.8 mm Hg (1 mm Hg=0.133 kPa) ( P <0.01)and lowered the ratio of left ventricular weight to body weight from 264.3±17.1 mg/100 g to 208.2±13.9 mg/100g ( P <0.01). AngⅡ levels were lowered in left ventricular myocardium and arterial wall ( P <0.01) but increased in plasma and kidney ( P <0.01). Conclusion Valsartan can inhibit tissue remodeling in left ventricle through AT 1 receptor and low AngⅡ levels.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1999年第6期456-458,共3页
Chinese Journal of Cardiology
