摘要
目的:研究免疫介导过程对增生性糖尿病性视网膜病变(proliferative diabetic retinopathy PDR)的发生发展的潜在作用。方法:应用特异性的抗辅助T淋巴细胞(CD4)、抗白细胞介素-2(interleukin-2 IL-2)及其受体的单克隆抗体(interleukin-2 receptor IL-2R),对经扁平部玻璃体切割术获得的15例PDR视网膜前膜标本进行了研究。结果:在15例标本中,12例(80%)呈CD4阳性;12例(80%)发现有IL-2,且其中11例也呈CD4阳性;10例(67%)发现有IL-2R,其中9例呈CD4阳性并有释放的IL-2。大多数IL-2R阳性的前膜都来自Ⅰ型糖尿病患者,其中40%的患者小于40岁。结论:研究证实了半数以上的糖尿病视网膜前膜中有激活的免疫细胞和释放的淋巴因子,揭示了免疫反应过程和淋巴因子的生物效应对PDR视网膜前膜的形成起重要作用,尤其在青年患者和Ⅰ型糖尿病患者。眼科学报1999;15:229-232。
Purpose: To investigate the potential contribution of immune-mediated processes to the
development of proliferative diabetic retinopathy (PDR), an immunohistochemical study
was undertaken to characterize the infiltrating immune cells in epiretinal membranes from
the eyes of patients with PDR.
Methods: A total of 15 PDR epiretinal membrane specimens obtained surgically from
pars plans vitrectomy were studied by using a panel of monoclonal antibodies against T
lymphocytes (CD4), interleukin-2(IL-2) and interleukin-2 recpetors(IL-2R).
Results:Twelve of 15 specimens (80%) contained CD4-positive cells. IL-2 was found
in 12 of 15 samples (80% ). of which 1 1 also contained CD4-positive cells, and IL-2R
was detected in 10 of 15 membranes (67% ), of which 9 contained CD4-positive cells
and released IL-2. Most of the IL-2R-positive membranes were from type I diabetic
patients, 40% of them are younger than 40 years.
Conclusion: Our study demonstrated the involvement of activated immune cells and
release of lymphokine(s) in more than half of the diabetic epiretinal membranes tested
and revealed that the processes of immune responses and the biological effects of lymphokines(s) may play an important part in the development of epiretinal membranes of PDR, especially in young-onset and type I diabetes. Eye Science 1999; 15; 229 -232
出处
《眼科学报》
1999年第4期229-232,共4页
Eye Science
基金
国家教委留学回国人员基金资助
关键词
激活
T淋巴细胞
增生病性
视网膜病变
activated T lymphocytes, epiretinal membranes, proliferative diabetic retinopathy
