摘要
目的探讨盐酸吡格列酮对2型糖尿病患者血管内皮功能和高敏C反应蛋白的影响。方法 65例2型糖尿病患者,口服给予盐酸吡格列酮15 mg,1次/d。观察治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HBALC)、内皮细胞蛋白C受体(EPCR)、血栓调节蛋白(TM)、血管性假血友病因子(vWF)和高敏C反应蛋白(hs-CRP)水平。结果患者治疗12周后,FBG2、h PG和HbA1水平明显降低(P<0.05),胰岛素抵抗指数和胰岛素敏感指数均明显改善(P<0.01)。血浆vWF、TM、EPCR和hs-CRP均明显下降(P<0.05)。结论盐酸吡格列酮能改善患者的血管内皮功能,降低高敏C反应蛋白水平。
Objective To explore the influence of Pioglitazone Hydrochloride on endothelial function and high sensitivity C-reactive protein in type 2 diabetes.Methods Sixty-five patients with type 2 diabetes were treated by oral administration of 15mg Pioglitazone Hydrochloride for 12 weeks.The changes of FPG,2 h PG,HBALC,vWF,TM,EPCR and high sensitivity C-reactive protein（hs-CRP） before and after treatment were observed.Results After 12 weeks of treatment,all the level of FPG,2 h PG and HBALC were significantly decreased（P0.05）.Both insulin resistance index and insulin sensitivity index were improved significantly（P0.05）.All the level of vWF、TM、EPCR and hs-CRP were significantly decreased（P0.05）.Conclusion Pioglitazone Hydrochloride has good effect on the improvement of vascular endothelial function and reducing the level of hs-CRP.
出处
《实用临床医药杂志》
CAS
2011年第13期29-31,共3页
Journal of Clinical Medicine in Practice
关键词
2型糖尿病
盐酸吡格列酮
血管内皮功能
高敏C反应蛋白
Type 2 diabetes
Pioglitazone Hydrochloride
endothelial function
high sensitivity C-reactive protein
