摘要
目的：探讨地塞米松（Ｄｅｘ） 对内毒素肺损伤的治疗机制，观察其对体内神经肽含量变化的影响。方法：制作绵羊慢性肺淋巴瘘模型，应用大肠杆菌内毒素静脉滴入导致急性肺损伤并使用大剂量Ｄｅｘ 防治，利用放免方法测定血浆、肺淋巴液神经肽含量及血浆皮质醇（ＣＳ） 含量变化。结果：内毒素致伤后血浆、肺淋巴液中血管活性肠肽（ ＶＩＰ） 和Ｐ 物质（ＳＰ） 含量及血浆ＣＳ 含量明显升高，大剂量Ｄｅｘ 可明显抑制这一变化。结论：大剂量Ｄｅｘ 对抗内毒素所致肺损伤的作用可能部分是通过调节体内神经肽及ＣＳ
AIM: To explore the therapeutic mechanism of dexamethasone(Dex)for acute lung injury induced by endotoxin and observe the effect of it on the level of neuropeptides in the animal body.METHODS:Inducing acute lung injury by infusing endotoxin intravenously on sheep with chronic lung lymph fistula, proventing and treating the lung injury with high-dose Dex and assaying the changed contents of the neuropeptides in plasma and lung lymph, as well as corticosterone(CS)contents in plasma by radioimmunoassay. RESULTS: The contents of vasoactive intestinal peptide(VIP)and substance P(SP) in plasma and lymph , CS in plasma increased significantly after endotoxin injection , and a high-dose Dex can reverse it. CONCLUSION: The protective function of high-dose Dex for endotoxin-induced lung injury may be partly by regulating the content of neuorpeptides and CS in the animal body.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第11期1006-1008,共3页
Chinese Journal of Pathophysiology
