摘要
目的了解耐碳青霉烯类抗菌药物病原菌的耐药机制,更合理地指导临床应用碳青霉烯类抗菌药物,降低多药耐药率。方法采用改良Hodge试验方法,同时采用双纸片法进行ESBLs酶检测。结果 145株多药耐药菌中44株(不动杆菌属40株,克雷伯菌属4株)产KPC型碳青霉烯酶。结论产KPC型碳青霉烯酶克雷伯菌属同时产ESBLs酶,耐碳青霉烯类抗菌药物不动杆菌属产KPC型检出率较高。
OBJECTIVE To understand the mechanism of drug resistance in carbopenems resistance pathogen, to provide more reasonable guidance for the use of carbapenems antibiotics for clinic,and reduce the rate of multidrug efflus. METHODS ESBLs enzyme was tested by Modified Hodge test and Double-paper method test. RESULTS 44 strains （40 strains Acinetobacter, 4 strains Klibsiella） with KPC producing carbopenems enzyme were detected out for 145 multidrug efflus strains. CONCLUSION Klibsiella producing KPC type of carbopenems enzyme can also produce ESBLs enzyme, the detection rate of KPC produced by Acinetobacter resistant to carbopenems antibiotics is relatively high.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第14期3042-3043,共2页
Chinese Journal of Nosocomiology
