摘要
目的:观察厄贝沙坦辅助治疗慢性心力衰竭的临床效果。方法:选取本院2009年5月～2010年8月收治的126例慢性心力衰竭患者,随机分为观察组(厄贝沙坦辅助治疗组)和对照组(常规治疗组)各63例,观察组患者在常规治疗(包括吸氧、洋地黄苷、利尿剂、ACEI、肾上腺素β-受体阻滞剂等)的基础上加用厄贝沙坦口服0.15 g,每日2次,病情稳定后给予0.3 g,每日1次。两组患者均持续治疗2周,比较两组患者治疗效果。结果:观察组显效32例,有效26例,总有效率为92.1%;对照组显效23例,有效28例,总有效率为80.9%。两组患者比较差异有统计学意义(P<0.01)。两组患者治疗后EF、SV、CI及E/A各项指标均有所改善,但观察组较对照组改善明显,差异有高度统计学意义(P<0.01)。两组患者治疗期间均无明显不良反应发生。结论:厄贝沙坦辅助治疗慢性心力衰竭可以显著提高临床治疗效果,改善患者心功能状态,值得临床推广使用。
Objective：To investigate the clinical effects of irbesartan in the treatment of chronic heart failure.Methods：126 cases with chronic heart failure in our hospital from May 2009 to August 2010 were randomly divided into observed group（irbesartan adjuvant therapy group） and control group（conventional treatment group）,with 63 cases in each group.The control group with conventional therapy（including oxygen,digitalis glycosides,diuretics,ACEI,adrenergic β-blocker,etc.）,the observed group with conventional combined irbesartan,0.15 g for each time,twice a day,after the disease was stable,0.3 g for each time,once a day.The treatment lasted for 2 weeks,and compared the clinical effects of the two groups.Results：In the observed group,32 cases markedly improved,26 cases were efficient,and the total effective rate was 92.1%.While in the control group,23 cases were markedly effective,28 cases were efficient,and the total effective rate was 80.9%.There was significant difference between the two groups（P0.01）.After the therapy,EF,SV,CI and E/A indexes between the two groups were obviously improved,and these items were significantly different between the observed group and the control group（P0.01）.The cases of the two groups had no obvious adverse reactions during treatment.Conclusion：Irbesartan can significantly improve clinical symptoms and improve heart function in adjuvant treatment of chronic heart failure,which is worthy of being promoted in clinical use.
出处
《中国医药导报》
CAS
2011年第20期129-130,共2页
China Medical Herald
关键词
厄贝沙坦
心力衰竭
效果
辅助治疗
Irbesartan
Heart failure
Clinical effects
Adjuvant treatment
