摘要
目的探讨上气道咳嗽综合征（UACS）患者外周血辅助性T细胞（Th）业群平衡偏移及其意义。方法收集78例UACS患者（慢性扁桃体炎25例、鼻后滴流综合征17例、过敏性鼻炎36例）。与40例健康体检者进行比较。以γ-干扰素（IFN-γ）代表Th1型细胞因子，白介素4（IL-4）代表Th2型细胞因子，ELISA法测定患者血清IL-27、IFN-γ、IL-4、肿瘤坏死因子a（TNF-a）浓度水平。结果正常组与UACS组之间比较，IL-27、IFN-γ、IL-4和TNF-γ差异有统计学意义，正常组IL-27和IFN-γ浓度高于UACS组，差异有统计学意义，正常组IL-4和TNF—a浓度低于UACS组，且UACS组Th1／Th2比例失衡。结论Th1、Th2细胞因子参与了UACS的发病，且Th1／Th2比例失衡可能是导致其发病的重要因素。
Objective The aim of study was to explore the significance of the imbalance of Th1/ Th2 in patients with upper airway cough syndrome（UACS）. Methods Serum IFN-γ, IL -27, IL- 4 and TNF-a were detected by enzyme linked immunosorbent assay （ELISA） in 78 patients with UACS and 40 heahh with person. Results Serum IFN-γ and IL- 27 level in 78 cases of the stage of attack were remarkably lower than those in 40 health person （P 〈 0.01 ）. Serum IL -4 and TNF-a level were remarkably higher than those in 40 health person（ P 〈0.01）. Conclusions The outbreak of UACS by Th1 and Th2 cytokines, and Th1/Th2 ratio imbalance may cause the disease of UACS.
出处
《国际呼吸杂志》
2011年第13期1008-1009,共2页
International Journal of Respiration
