摘要
目的 通过检测不同原因不孕症患者血清、腹腔液中抗子宫内膜抗体(EMAb)及γ-干扰素(IFN-γ)的含量、分布情况及其与子宫内膜异位症病变程度的关系,探讨EMAb、IFN-γ在诱发不孕中的作用,为临床诊断及治疗不孕症提供理论依据。方法 采用ELISA法检测EMAb及IFN-γ。结果 内异症组血清中EMAb水平明显高于结核组与正常组(P<0.01),内异症组III-IV期与I-II期比较无显著性差异(P>0.05)。各组腹腔液中EMAb水平无显著性差异(P>0.05), 结核组血清、腹腔液中IFN-γ水平明显高于EM组、正常组(P<0.01),内异症组血清、腹腔液中IFN-γ水平与正常组比较无显著性差异(P>0.05)。结论 各观察组血清中IFN-γ水平与腹腔液中无显著相关,提示临床应用血清EMAb作为EM的辅助诊断指标;针对不同原因的不孕症,选用不同的细胞因子作为检测指标。
Objective In order to explore the effect of EMAb、IFN-γin differ reasions barrenwomen. We had test EMAb、IFN-γ were in serum and celica fluid to investigate the distribution and therelation with EM degree. Methods We test all sample of EMAb、IFN-γin ELISA method.Result Thepositive rate of EMAb in EM I-II and III-IV were significantly higher than in normal control and TB group(P<0.01)but not different between EM I-II and III-IV (P>0.05). The rate of EMAb in celica fluid werenot different in differ groups(P>0.05). IFN-γ lever in serum and celica fluid of TB group weresignificantly higher than in EM and normal control group(P<0.01). IFN-γ lever in serum and celicafluid of EM group were not different with normal control group(P>0.05).Conclusion IFN-γ leverin serum of differ group were not significantly correlation with that in celica fluid.This clue to usthat we should take EMAb as EM assistant diagnose guideline in clinic,and aim at differ reasons barrentake differ cellgene.
出处
《国际医药卫生导报》
2003年第12期11-12,共2页
International Medicine and Health Guidance News
