摘要
目前研究已发现RhoA/Rho激酶信号通路参与了人体多种疾病的形成,如高血压、冠心病、脑率中等。肺动脉高压的病理学改变包括内皮细胞的损伤、增殖,肺血管平滑肌细胞的高反应性,炎症细胞迁移和黏附以及肺小血管形成和栓塞;Rho激酶调节细胞的多种生物学行为和功能,如收缩、黏附、迁移、增殖、凋亡、基因表达等。研究表明RhoA/Rho激酶信号通路通过多种方式参与了肺动脉高压的形成。
It has been shown that RhoA/Rho kinase signaling pathway is involved in the pathogenesis of multiple human diseases such as hypertension,coronary heart disease,stroke and so on.Pathological changes of pulmonary arterial hypertension include endothelial cell damage,proliferation,hyper-responsiveness of pulmonary vascular smooth muscle cells,inflammatory cell migration and adhesion,angiogenesis,and pulmonary embolism.Rho kinase regulates lots of biological cellular functions such as contraction,adhesion,migration,proliferation,apoptosis,gene expression and so on.Thre is ample evidence suggests that RhoA/Rho kinase signaling pathway is involved in the development of pulmonary hypertension.
出处
《国际病理科学与临床杂志》
CAS
2011年第3期256-258,共3页
Journal of International Pathology and Clinical Medicine
关键词
RHOA/RHO激酶
肺动脉高压
肺高压
Rho-kinase
pulmonary arterial hypertension
pulmonary hypertension
