摘要
炎症细胞和结构细胞促进哮喘患者支气管的急性收缩和慢性气道重建。当前哮喘的治疗不能有效地抑制气道高反应性和气道重建。近来发现Rho激酶在哮喘的发病中起重要作用,而Rho激酶抑制剂可抑制气道平滑肌收缩、调节气道平滑肌特异性的基因转录、减轻气道壁增厚和气道炎症,从而减轻急性和慢性气道高反应性。
In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodeling. Current asthma therapy doesnot effectively inhibit these features. Recently, accumulating evidence has been suggested that activation of the Rho-kinase pathway is substantially involved in the pathogenesis .of asthma andthat Rho-kinase inhibitors attenuate acute and chronic airway hyperreponsiveness via inhibiting airway smooth muscle contraction, airway smooth muscle specific gene transcription, regulating reducing airway wall thickening and decreasing inflammation. Rho-kinase and its inhibitor play a pivotal role for this pathway in acute and chronic airway airway hyperreponsiveness.
出处
《国际病理科学与临床杂志》
CAS
2006年第6期499-502,共4页
Journal of International Pathology and Clinical Medicine
关键词
RHO激酶
气道高反应性
气道重建
气道平滑肌
气道炎症
Rho-kinase
airway hyperresponsiveness
airway remodeling
airway smooth muscle
airway inflammation
