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Rho/Rho激酶信号通路与肺部疾病 被引量：5

Rho/Rho-kinase signaling pathway and pulmonary disease
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摘要 Rho通过GTP结合形式和GDP结合形式的转换起着分子开关的作用,调控许多细胞内信号通路。Rho通过激活其下游靶分子Rho激酶调节细胞的收缩、黏附、迁移、增殖、凋亡等多种生物学行为和功能。目前已证实Rho/Rho激酶通路参与肺动脉高压、哮喘、特发性肺纤维化和肺癌等多种肺部疾病的病理生理过程,在这些疾病的动物模型中阻断该信号通路能够改善这些疾病的病理改变与预后。 Rho exhibits both GDP/GTP-binding activity and functions as a molecular switch, cycling between a GDP-bound inactive state and a GTP-bound active state. Activated RhoA via its downstream effector Rho-kinase is involved in a wide range of cellular functions, such as cell contraction, adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence has been suggested that activation of the Rho/Rho-kinase signaling pathway is substantially involved in the pathogenesis of several pulmonary diseases, such as pulmonary hypertension, asthma, idiopathic pulmonary fibrosis and lung cancer, while inhibitors of Rho/Rho-kinase signaling pathway can improve the outcome of these diseases in animal models.
作者 邢西迁 甘烨 吴尚洁
机构地区 中南大学湘雅二医院呼吸内科
出处 《国际病理科学与临床杂志》 CAS 2007年第1期85-88,共4页 Journal of International Pathology and Clinical Medicine
关键词 RHO激酶 肺动脉高压 哮喘 特发性肺纤维化 肺癌 Rho-kinase pulmonary hypertension asthma idiopathic pulmonary fibrosis lung cancer
分类号 R563 [医药卫生—呼吸系统]
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参考文献23

  • 1Nagaoka T,Gebb S A,Karoor V,et al.Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat[J].J Appl Physiol,2006,100(3):996-1002.
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二级参考文献26

  • 1郑文建,梁平.Rho亚家族蛋白与恶性肿瘤的侵袭和转移[J].国际病理科学与临床杂志,2006,26(4):286-290. 被引量：5
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  • 6Schaafsma D,Gosens R,Bos I S,et al.Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction[J].Br J Pharmacol,2004,143(4):477-484.
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国际病理科学与临床杂志
2007年 第1期

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