摘要
目的探讨北京市手足口病流行对急性弛缓性麻痹（ASP）发病的影响及其流行病学联系。方法分析2006--2008年北京市AFP发病情况。对AFP病例利用RD、L20B细胞分离及鉴定病毒，并对非脊髓灰质炎肠道病毒（NPEV）阳性标本进行肠道病毒71型（EV71）和柯萨奇病毒A16型（CoxA16）检测。通过国家法定传染病报告系统收集2008年北京市手足口病发病数据，并对北京市2008年AFP发病情况与手足口病流行特点进行比较和分析。结果2006—2008年北京市AFP报告病例数从108例增加到177例，NPEV分离率从11．11％上升到20．34％，EV71和CoxA16两种病毒总检出率从0．93％上升到10．17％。结论EV71和CoxA16可能是AFP发病增加的重要原因。这部分病例并不表现出疹等手足口病的典型症状，而是以AFP为惟一表现，尤其是在手足口病流行期，这部分病例所占比例更高。
Objective To study the prevalence of acute flaccid paralysis （AFP） and hand foot mouth disease （HFMD） in Beijing, from 2006-2008. Methods Data on AFP and HFMD was analyzed epidemiologically, during 2006-2008 in Beijing. All the specimens from AFP cases were isolated and identified by RD and L20B cell and all of non-polio enterovirus （NPEV） cases were assayed by HFMD real-time PCR kit. The relationship between AFP and HFMD was analyzed. Results During 2006-2008, the number of AFP case in Beijing increased from 108 to 177 while the NPEV isolation rate increased from 11.11% to 20.34% and the positive rate of enterovirus 71 （EV71 ） and/or coxsackie virus A16 （Cox A16） increased from 0.93% to 10.17%. Conclusion The prevalence of HFMD caused by EV71 and/or Cox A 16 might have contributed to the increase of AYP cases in Beijing.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2011年第7期681-684,共4页
Chinese Journal of Epidemiology
