摘要
目的：采用缩窄腹主动脉造成压力负荷性心肌肥厚大鼠模型，观察血管紧张素转换酶抑制剂陪多普利早期给药对心室重构的预防作用以及相应的心肌组织病理学改变。方法：大鼠分三组，正常对照组、心肌肥厚组和陪多普利治疗组。治疗组在模型制备手术后即开始给药至１２周。心肌组织ＨＥ染色和胶原ＶＧ 染色，图像分析系统测量心肌细胞横径（ＴＤＭ）、心肌胶原容积分数（ＩＣＶＦ）和血管周围胶原面积（ＰＶＣＡ）。结果：在压力负荷增加致心肌肥厚过程中，同时有心肌细胞和间质胶原二方面重构改变；陪多普利早期给药能明显减轻心肌细胞和间质胶原重构发生。
Aim:To determine the preventive effect of ventricular remodeling,and myocardium histopathology by early using perindopril. Method:Partial ligation of the abdominal aorta of rats was carried to induce left ventricle hypertophy. After operation, perindopril(1 mg·kg -1 ·d -1 ) was given to the rats for 12 weeks. Morphological study of muscle cell transection diameter(TDM),collagen volume fraction(ICVF) and perivascular collagen area(PVCA) were carried by HE and collagen VG staining using image analysis system. Results: During ventricular remodeling,myocardial cells and interstitial collagen were remodeling simultaneously.TDM,ICVF and PVCA were increased significantly. Perindopril significantly reduced left ventricular weight,TDM,ICVF and PVCA in the hypertrophy rat. Conclusion: The results suggests that early using of perindopril could partially prevent ventricular remodeling induced by pressure overload.
出处
《高血压杂志》
CSCD
1999年第4期384-387,共4页
Chinese Journal of Hypertension
