摘要
目的了解心肌肥厚时局部和循环内皮素（ＥＴ）的变化。方法采用腹主动脉缩窄法，造成大鼠压力负荷性心肌肥厚模型，用放免法测定血浆和心肌组织ＥＴ含量，并观察它们与左室重量（ＬＶＷ）、左室重量／体重比值（ＬＶＷ／ＢＷ）、心肌细胞直径（ＤＣ）的相关性。结果手术组心肌ＥＴ（１９．９８±４．１２ｐｇ／ｍｇ）及血浆ＥＴ（７０８．３±８３．６０ｐｇ／ｍｌ）均较对照组（分别为７．９１±２．２５ｐｇ／ｍｇ及５１４．４±７１．３７ｐｇ／ｍｌ）升高，并与ＬＶＷ、ＬＶＷ／ＢＷ及ＤＣ呈正相关（ｒ分别为０．７５１９，０．８５９１，０．７２８３）。结论心肌肥厚时心肌及血浆ＥＴ均升高。
Objective\ To determine the changes of cardiac and plasma endothelin in cardiac hypertrophy,and the relationship between endothelin and cardiac hypertrophy.\ Mothods\ Cardiac hypertrophy was produced by pacing a constricting clip around the suprarenal abdominal aorta of rats,the cardiac endothelin and plasma endothelin were measured by means of enzymatic immunoassay.\ Results\ Both cardiac and plasma endothelin(19.98±4.12 pg/mg,708.3±83.6 pg/ml) were increased and positively related to left ventricular weight (LVW,r= 0.7519 ),LVW/BW(body weight,r=0.8591) and diameter of cardiomyocytes(r= 0.7283 ) .\ Conclusion\ Cardiac and plasma endothelin were increased in cardiac hypertrophy and endothelin was involved in the development of cardiac hypertrophy.
出处
《福建医科大学学报》
1998年第2期132-135,共4页
Journal of Fujian Medical University
