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IL-18在糖尿病肾病发病过程中的作用 被引量:10

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摘要 糖尿病肾病(diabetic nephropathy,DN)是糖尿病最常见的微血管并发症之一,其临床特征为蛋白尿,渐进性肾功能损害,高血压,水肿,晚期出现严重肾衰竭.随着糖尿病发病人数的逐年增多,DN的发病率也逐渐增高.在美国,DN已成为终末期肾脏疾病的首位原因.在国内,DN所导致的肾衰竭亦日益增多,因此,DN作为糖尿病患者致残和死亡的主要原因之一逐渐被人们所重视.但是,DN的确切发病机制在很大程度上还不明确,诸多因素在DN的发生机制中起着重要作用.近年来多项研究显示,IL-18参与DN的发生发展过程.
出处 《中国中西医结合肾病杂志》 2011年第5期454-456,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 浙江省中医药管理局基金资助项目(No.2009CA087) 杭州市科技局基金资助项目(No.20100733Q29)
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  • 1Okamura H,Tsutsi H,Komatsu TM,et al.Cloning of a newcytokine that induces IFN-γ production by T cells.Nature,1995,378(2):88-91.
  • 2Jin M,J ung HJ,Choi JJ,et al.Activation of selective transcription factors and cytoki-nes by watersoluble ext ract from Lentinus Iepideus.Ex Perimental Biology and Medici-ne,2003,228(6):749.
  • 3Skurk T,Kolb H,Muller-Scholze S,et al.The proatherogenic cytokine interleukin-18 is secreted by human adipocytes.Eur J Endocrinol,2005,152(6):863-868.
  • 4Shui HA,Ka SM,Wu WM,et al.LPS-evoked IL-18 expression in mesangial cells plays a role in accelerating lupus nephritis.Rheumatology,2007,46(8):1277-1284.
  • 5Szeto CC,Chow KM,Poon PY,et al.Assocaiation of interleukin-18 promoter polymorphism and atherosclerotic diseases in Chinese patients with diabetic nephropathy.J Nephrology,2009,14(6):606-612.
  • 6许勇芝,陈孝文,刘华锋,唐德燊,梁东,江黎明,刘海燕,吴平.糖尿病肾病患者外周血IL-18表达的研究[J].中国中西医结合肾病杂志,2002,3(11):645-647. 被引量:5
  • 7付秀立,李竞.白细胞介素-18、-6在糖尿病大鼠肾脏的表达[J].武汉大学学报(医学版),2007,28(5):602-604. 被引量:3
  • 8陈宝平,杨素霞,时军,陈芳,赵清.2型糖尿病肾病患者血清IL-18水平测定[J].郑州大学学报(医学版),2008,43(6):1159-1161. 被引量:5
  • 9Nvarro-Gonzales JF,Jarque A,Muros M,et al.Tumor necrosis factoralpha a therap-eutic target for diabetic nephropathy.Cytokine Growth Factor Rev,2009,20(2):165-173.
  • 10Goldberg RB.Cytokine and cytokine-like inflammation markers,endothelial dysf-unction,and imbalanced coagulation in development of diabetes and its compicat-ions.J Clin Endocrinol Metab,2009,94(9):3171-3182.

二级参考文献50

  • 1周希静.糖尿病肾病的早期诊断与鉴别诊断[J].实用内科杂志,1993,13(5):262-263. 被引量:25
  • 2梅妍,周鸿鹰,李爱冬,卢友光,羊惠君.白介素-18及信号转导和转录激活因子5在糖尿病大鼠视网膜的表达[J].中华眼底病杂志,2005,21(4):258-260. 被引量:14
  • 3赵豫梅,吴于滨,宋滇平.糖尿病肾病分子病因学研究进展[J].昆明医学院学报,2007,28(02B):96-99. 被引量:3
  • 4Fornoni A, Ijaz A, Tejada T, et al. Role of inflammation in diabetic nephropatby [J]. Curr Diabetes Rev,2008,4 ( 1 ) : 10
  • 5Navarro JF, Mora C. Diabetes, inflammation, proinflammatory cytokines and diabetic nephropathy[ J ]. Scientific World Journal ,2006,6:908
  • 6Kosugi T, Yuzawa Y, Sato W, et al. Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy [ J ]. Lab Invest, 2007,87 ( 9 ) : 903
  • 7Shikata K. Microinflammation in the pathogenesis of diabetic nephropathy [ J ]. Nippon Jinzo Gakkai Shi, 2007, 49 (5) :474
  • 8Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells [J]. Nature,1995,378(6 552) :88
  • 9Esfandiari E, Mclnnes IB, Lindop G. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease[J]. J Immunol, 2001,167(9) : 5 338
  • 10Mahmoud RA, el-Ezz SA, Hegazy SA. Increased serum levels of interleukin-18 in patients with diabetic nephropathy[J]. Ital J Biochem,2004,53(2):73

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