摘要
目的了解血小板ADP受体抑制率对血凝块形成的影响,及其与年龄、性别的关系。方法联用氯吡格雷和阿司匹林的急性冠脉综合征80例,血栓弹力图测定血小板ADP受体抑制率和ADP通道的R时间、K时间、α角、MA值和TMA。结果 80例患者ADP受体抑制率为66.4±24.6%,R时间为0.7±0.4 m in,α角为54.8°±13.7,°MA值为27.1±15.0 mm,TMA为15.9±7.8 m in,K时间为6.2±4.6 m in(n=51)。ADP受体抑制率对R时间无影响(P>0.05);随抑制率增高,α角缩小,MA值降低,TMA缩短,K时间延长并且无K时间病例增多(P<0.05)。各年龄段之间、男女患者之间ADP受体抑制率比较均无差别(P>0.05)。结论抑制血小板ADP受体不利于血凝块形成,随抑制率增高,血凝块形成减慢、强度变小;抑制率大小与年龄性别无关。
Objective To study the inhibitory effect of ADP receptor in platelets on clot formation and its association with age and gender.Methods 80 patients with acute coronary syndrome were treated with clopidogrel（75 mg） in combination with aspirin（100 mg） daily.Inhibitory rate of ADP receptor in platelets were detected by thromboelastography.The following variables of ADP channel were also recorded： R time,K time,α angle,maximum amplitude（MA） and time to MA（TMA）.Results The inhibitory rate of ADP receptor was 66.4±24.6%.The R time,α angle,MA and TMA of ADP channel were 0.7±0.4 min,54.8°±13.7 °,27.1±15.0 mm and 15.9±7.8 min,respectively.The K time was 6.2±4.6 min（n=51）,with 29 cases having no K time because of MA20 mm.Inhibition of ADP receptor had no effect on R time（P 0.05）.The α angle became smaller,the MA decreased,and the TMA became shorter with the increasing ADP receptor inhibition rate（P0.05）.The number of cases having no K time was increased when the K time became longer.Comparison of inhibition rate between different age group,between male and female was not significant（P 0.05）.Conclusion Inhibition of ADP receptor in platelets is not favorable for clot formation.The speed and strength of clot formation decrease with the increasing inhibitory rate.The inhibition rate of ADP receptor is not influenced by age and gender.
出处
《血栓与止血学》
2011年第3期121-123,共3页
Chinese Journal of Thrombosis and Hemostasis
