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HIV感染的CD4^+T淋巴细胞损伤机制 被引量：23

CD4^+T cell depletion and dysfunction in HIV infection
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摘要 人类免疫缺陷病毒（HIV）感染引起机体免疫功能进行性受损,从而导致各种机会性感染和肿瘤。HIV对机体免疫系统的各个组成部分均可造成直接或间接的损伤。
作者 谢静 李太生
机构地区 中国医学科学院北京协和医学院北京协和医院感染科
出处 《中国病毒病杂志》 CAS 2011年第3期167-170,共4页 Chinese Journal of Viral Diseases
基金 国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX10001-006) 国家自然科学基金项目(81071372) 卫生部部属(管)医疗机构临床学科重点项目(2010-2012)
关键词 人类免疫缺陷病毒 获得性免疫缺陷综合征 CD4+T淋巴细胞 Human immunodeficiency virus Acquired immunodeficiency syndrome CD4＋ T lymphocyte
分类号 R512.91 [医药卫生—内科学]
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参考文献20

  • 1谢静,韩扬,李太生,邱志峰,左玲燕,李雁凌,王爱霞.T细胞第二信号受体-CD28分子在HIV/AIDS患者中的异常改变[J].中国医学科学院学报,2006,28(5):618-621. 被引量：5
  • 2Porter KA,Kelley LN,Nekorchuk MD,et al.CIITA enhancesHIV-1 attachment to CD4+T cells leading to enhanced infec-tion and cell depletion. J Immunol . 2010
  • 3Schnittman SM,Lane HC,Greenhouse J,et al.Preferentialinfection of CD4+memory T cells by human immunodeficiencyvirus type 1:evidence for a role in the selective T-cell func-tional defects observed in infected individuals. Proceedings of the National Academy of Sciences of the United States of America . 1990
  • 4Bandera A,Ferrario G,Saresella M,et al.CD4+T cell deple-tion,immune activation and increased production of regulatoryT cells in the thymus of HIV-infected individuals. PLoSOne . 2010
  • 5Godet AN,Guergnon J,Croset A,et al.PP2A1 binding,celltransducing and apoptotic properties of Vpr (77-92):a newfunctional domain of HIV-1 Vpr proteins. PLoS One . 2010
  • 6Salghetti S,Mariani R,Skowronski J.Human immunodeficiencyvirus type 1 Nef and p56lck protein-tyrosine kinase interactwith a common element in CD4 cytoplasmic tail. Proceedings of the National Academy of Sciences of the United States of America . 1995
  • 7RoserbergYJ,AndersonA,PabstR.HIV induceddeclineinbloodCD4/CD8ratios:viralkillingoralteredlymphocytetraf ficking. Immunology Today . 1998
  • 8P. D. Katsikis,E. S. Wunderlich,C. A. Smith.Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. The Journal of Experimental Medicine . 1995
  • 9Ho DD,Neumann AU,Perelson AS,et al.Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature . 1995
  • 10Mehandru S,Poles MA,Tenner-Racz K,et al.Lackof mucosal immune reconstitution during prolonged treatment of acute and early HIV-1infection. PLoS Med . 2006

二级参考文献9

  • 1Choi BS,Park YK,Lee JS.The CD28/HLA-DR expressions on CD4 + T but not CD8 + T cells are significant predictors for progression to AIDS.Clin Exp Immunol,2002,127 (1):137-144.
  • 2Sharpe AH,Freeman GJ.The B7-CD28 superfamily.Nat Rev Immunol,2002,2(2):116-126.
  • 31993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults.MMWR Recomm Rep,1992,41(RR-17):1-19.
  • 4Ostrowski SR,Gerstoft J,Pedersen BK,et al.A low level of CD4 + CD28 + T cells is an independent predictor of high mortality in human immunodeficiency virus type 1-infected patients.J Infect Dis,2003,187(11):1726-1734.
  • 5Sacre K,Carcelain G,Cassoux N,et al.Repertoire,diversity,and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease.J Exp Med,2005,201(12):1999-2010.
  • 6Appay V,Dunbar PR,Callan M,et al.Memory CD8 + T cells vary in differentiation phenotype in different persistent virus infections.Nat Med,2002,8(4):379-385.
  • 7Lange CG,Lederman MM,Medvik K,et al.Nadir CD4 + T-cell count and numbers of CD28 + CD4 + T-cells predict functional responses to immunizations in chronic HIV-1 infection.AIDS,2003,17(14):2015-2023.
  • 8Autran B,Carcelain G,Li TS,et al.Positive effects of combined antiretroviral therapy on CD4 + T cell homeostasis and function in advanced HIV disease.Science,1997,277 (5322):112-116.
  • 9邱志峰,王爱霞,陈鸿珊,盛瑞媛.用流式细胞仪检测HIV感染者和AIDS患者的T细胞亚群[J].中华实验和临床病毒学杂志,1999,13(1):45-47. 被引量：29

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中国病毒病杂志
2011年 第3期

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