摘要
目的研究改性壳聚糖防粘连膜用于预防开腹手术后肠粘连的临床效果。方法复旦大学附属中山医院普外科2006年1—12月间的240例腹部外科手术病例，随机分成两组，试验组关闭腹部切口前在手术创面和切口下放置改性壳聚糖防粘连膜，对照组则不放置。观察术后胃肠道功能恢复情况，术后腹痛程度和持续时间，手术后并发症发生率，并随访术后1年内腹痛和粘连性肠梗阻的发生率。结果试验组术后腹痛症状较对照组明显减轻，术后肠道功能恢复和进食时间明显早于对照组，术后1年内粘连性肠梗阻发生率明显下降。术后并发症发生率两组间无明显统计学差异。结论改性壳聚糖防粘连膜的使用有助于改善腹部外科术后腹腔粘连，减少粘连性肠梗阻的发生。
Objective To evaluate a chemically-modified chitosan anti-adhesion film in the prevention of intestinal adhesion after abdominal surgery. Method In this study 240 patients at the Department of Surgery, Fudan University Zhongshan Hospital undergoing abdominal surgery from Jan 2006 to Dec 2006 were randomly divided into two groups. In the research group, chemically-modified chitosan anti adhesion film was put both at the area of operation and under the incision before closing the abdomen. The recovery procedures were recorded including the recovery of gut movement, the degree and the lasting time of abdominal pain, complication after surgery, the abdominal pain and ileus within 1 year. Result Postoperative incision pain was less significant in research group. The gut function recovered quicker and dietary began earlier. The ratio of early ileus after the surgery decreased significantly. The abdominal adhesion symptom in 1 year after surgery ameliorated significantly. There was no significant difference in other postoperative complications in the two groups. Conclusion The use of chemically- modified chitosan anti-adhesion film helps to prevent the intestinal adhesion after the abdominal surgery.
出处
《中华普通外科杂志》
CSCD
北大核心
2011年第5期414-416,共3页
Chinese Journal of General Surgery
关键词
手术后并发症
腹腔
粘连
改性壳聚糖防粘连膜
Postoperative complications
Abdominal cavity
Adhesions
Chemically-modified ehitosan, anti-adhesion film
