摘要
目的探讨水蛭肽注射液对脑神经保护作用机制。方法采用栓线法阻塞大鼠大脑中动脉,制作MCAO模型即脑缺血再灌注损伤模型。实验动物脑缺血再灌注后进行神经功能评分并观察脑组织神经细胞凋亡的形态,计算脑组织神经细胞凋亡的百分率。结果水蛭肽注射液能降低损伤后大鼠神经功能评分,能抑制再灌注损伤后脑组织神经细胞凋亡。与川芎嗪对照组相比,差异有统计学意义(P<0.01)。结论水蛭肽注射液能减低脑神经细胞凋亡的发生率,对缺血脑组织具有保护作用。
objective To study the cranial nerve protection leech peptide injection mechanism.Methods Using plugs line method jams rat MCA,making MCAO model namely cerebral ischemia-reperfusion injury model.Experimental animals after cerebral ischemia and reperfusion neurobehavioral scores and observe the brain nerve cell apoptosis,brain nerve cells form calculated as a percentage of apoptosis.Results Leeches peptide injection can reduce damage rats after neurobehavioral scores,can restrain reperfusion injury afterbrain organization nerve cell apoptosis.Compared with control group of ligustrazine,difference was statistically significant（P0.01）.Conclusion Leeches peptide injection can reduce the incidence of nerve cell apoptosis of ischemic brain,with protection.
出处
《当代医学》
2011年第17期16-17,共2页
Contemporary Medicine
关键词
水蛭肽注射液
0神经细胞凋亡
Leeches peptide injection
Nerve cell apoptosis
